Fused benzazepine derivatives for use in the treatment of cancer and epilepsy

A compound of formula (I) or a pharmaceutically acceptable salt thereof,

• Wherein
• Y represents N—Ra or CR1aR1b;
• Ra represents hydrogen or C1-4 alkyl;
• R1a and R1b represent independently hydrogen, hydroxy, halogen;
• or C1-4 alkoxy or C1-4 alkyl, either of which groups may be optionally substituted with one or more substituents;
• and
• A, together with the points of attachment to the remainder of the molecule, V3 and V4, represents an optionally substituted aryl or heteroaryl selected from the groups represented by A1, A2, A3, A4, A5, A6 and A7:
• Wherein
• V3 and V4 represent independently C;
• Z1 represents N or C—R4;
• Z2 represents N or C—R5;
• Z3 represents N or C—R6;
• Re represents hydrogen or halogen;
• R4 represents hydrogen, halogen, hydroxy, cyano or amino;
• or C1-4 alkyl, C3-7 cycloalkyl or C1-4 alkoxy, any of which groups may be optionally substituted by one or more substituents;
• R5 represents hydrogen, halogen or cyano;
• or C1-4 alkyl or C1-4 alkoxy, either of which groups may be optionally substituted by one or more substituents;
• R6 represents hydrogen, halogen, or cyano;
• or C1-4 alkoxy, C1-4 alkylamino, C1-4 alkyl, C3-7 heterocycloalkyl or —O—(C3-7 heterocycloalkyl), any of which groups may be optionally substituted by one or more substituents;
• R7 represents hydrogen;
• or C1-4 alkyl or C3-7 cycloalkyl, either of which groups may be optionally substituted by one or more substituents;
• R8, R9 and R10 independently represent hydrogen or halogen;
• or C1-4 alkyl, C3-7 cycloalkyl or C1-4 alkoxy, any of which groups may be optionally substituted by one or more substituents;
• R11 represents —NRc—(CO)—Rb;
• Rb and Rc represent independently C1-4 alkyl;
• and
• B, together with the points of attachment to the remainder of the molecule, V1 and V2, represents an optionally substituted aryl or heteroaryl selected from the groups represented by B1, B2, B3, B4, B5, B6, B7 and B8:
• Wherein
• V1 represents C for B1, B2, B3, B4, B5, B6 and B7 and represents N for B8;
• V2 represents C for B1, B2, B4, B6, B7, and B8 and represents N for B3 and B5;
• W, U1 and U2 represent independently N or C—H;
• Z4 represents N or C—R13;
• Z5 represents N or C—R14;
• Z6 represents N or C—R15;
• Z7 represents N or C—R16;
• T represents N or C—R17;
• R12 represents hydrogen;
• R13, R14, R15, R16 represent independently hydrogen, halogen, or cyano;
• or C1-4 alkyl or C1-4 alkoxy, either of these groups which may be optionally substituted by one or more substituents;
• R17 represents hydrogen, halogen or C1-4 alkyl;
• R17′ represents hydrogen or C1-4 alkyl;
• and
• Q represents a ring selected from the groups represented by Q1 and Q2:
• Wherein
• Z8 represents N or C—R3;
• Z9 represents C—R18;
• Z10 represents N or C—R19;
• Z11 represents C—R20;
• Z12 represents S, O, N—H or CR21R22;
• Z13 represents N or C—R23;
• Z14 represents N or C—R24;
• R2 represents halogen, or cyano;
• or C1-4 alkyl, C3-7 cycloalkyl or C1-4 alkoxy, any of which groups may be optionally substituted by one or more substituents;
• R3 represents hydrogen, halogen or cyano;
• or C1-4 alkyl, which group may be optionally substituted by one or more substituents;
• or
• R2 and R3 together with the group to which they are attached form a cycloalkyl, heterocyclyl, aryl or heteroaryl, which group is optionally substituted with one or more substituents;
• R18 represents hydrogen or halogen;
• or C1-4 alkyl which may be optionally substituted by one or more substituents;
• and
• R19, R20, R21, R22, R23 and R24 represent independently hydrogen or halogen;
• or C1-4 alkyl which may be optionally substituted by one or more substituents.