Heterocyclic compounds, preparation method therefor and use thereof

A compound, or a pharmaceutically acceptable salt,

• stereoisomer, ester, prodrug, solvate, or deuterated compound thereof, having the following structure:
• wherein,
• Q1-ring is an aliphatic ring, an aromatic ring, or a heterocyclic ring;
• Q2-ring is an aliphatic ring, an aromatic ring, or a heterocyclic ring;
• Q3-ring is an aliphatic ring, an aromatic ring, or a heterocyclic ring;
• R01, R02, and R03 are each one or more independent substituents on the Q1-ring, Q2-ring, and Q3-ring, they are each selected from a group consisting of H, D, ═O, halogen, cyano, nitro, azido, —OR04, —C(O)R04, —C(O)OR04, —NR05C(O)OR04, —OC(O)R04, —NR05SO2R04, —SO2NR04R05, —NR05C(O)R04, —C(O)NR04R05, —NR04R05, —SR04, —S(O)R04, —S(O)2R04, —SO3H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t1(C6-C10 aryl), —SO2(CH2)t1(C6-C10 aryl), —S(CH2)t1(C6-C10 aryl), —O(CH2)t1(C6-C10 aryl), —(CH2)t1(4-10 membered heterocyclyl), —SO2(CH2)t1(4-10 membered heterocyclyl), —S(CH2)t1(4-10 membered heterocyclyl), —O(CH2)t1(4-10 membered heterocyclyl), —(CH2)t1(C3-C10 cycloalkyl), —SO2(CH2)t1(C3-C10 cycloalkyl), —S(CH2)t1(C3-C10 cycloalkyl), and —O(CH2)t1(C3-C10 cycloalkyl), and t1 is an integer selected from 0 to 10;
• wherein 0-6 methylene units in the C1-C10 alkyl are optionally substituted with groups selected from -Cy-, —O—, —S—, —S—S—, —Si—, —C(O)—, —C(S)—, —C(O)O—, —OC(O)—, —OC(O)O—, —C(O)N(R04)—, —N(R04)C(O)—, —N(R04C(O)O—, —N(R04)C(O)N(R05)—, —N(R04)—, —S(O)2—, —S(O)2N(R04)—, —N(R04)S(O)2—, —S(O)—, —S(O)N(R04)—, —N(R04)S(O)—, —OP(O)(OR04)O—, —P(O)(OR04)O—, —P(O)—, —OP(O)N(R04)—, —P(O)N(R04)-, —P(O)(N(R04R05))—, —OP(O)(OR04)2N(R05)—, —P(O)(OR04)2N(R05)—, —N(R04)P(O)(OR05)O—, —N(R04)P(O)—,
• and m1 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, and 4-10 membered heterocyclyl is optionally substituted with one or more R06 groups;
• each R04 and R05 are independently selected from a group consisting of H, D, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t1(C6-C10 aryl), —(CH2)t1(4-10 membered heterocyclyl), and —(CH2)t1(C3-C10 cycloalkyl), and t1 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, and 4-10 membered heterocyclyl is optionally substituted with one or more R06 groups;
• each R06 is selected from a group consisting of D, halogen, cyano, nitro, azido, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, —OR07, —C(O)R07, —C(O)OR07, —NR08C(O)OR07, —OC(O)R07, —NR08SO2R07, —SO2NR07R08, —NR07C(O)R08, —C(O)NR07R08, —NR07R08, —SR07, —S(O)R07, —S(O)2R07, —SO3H, —(CH2)t2(C6-C10 aryl), —SO2(CH2)t2(C6-C10 aryl), —S(CH2)t2(C6-C10 aryl), —O(CH2)t2(C6-C10 aryl), —(CH2)t2(4-10 membered heterocyclyl), —SO2(CH2)t2(4-10 membered heterocyclyl), —S(CH2)t2(4-10 membered heterocyclyl), —O(CH2)t2(4-10 membered heterocyclyl), —(CH2)t2(C3-C10 cycloalkyl), —SO2(CH2)t2(C3-C10 cycloalkyl), —S(CH2)t2(C3-C10 cycloalkyl), and —O(CH2)t2(C3-C10 cycloalkyl), and t2 is an integer selected from 1 to 10;
• each R07 and R08 are independently selected from a group consisting of H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t(C6-C10 aryl), —(CH2)t(4-10 membered heterocyclyl), and —(CH2)t(C3-C10 cycloalkyl);
• each R07 and R08 are independently selected from a group consisting of H, D, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t3(C6-C10 aryl), —(CH2)t3(4-10 membered heterocyclyl), and —(CH2)t3(C3-C10 cycloalkyl), and t3 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, and 4-10 membered heterocyclyl is optionally substituted with D, halogen, cyano, nitro, azido, C1-C10 alkyl, —N(C0-C10 alkyl)(C0-C10 alkyl), —O(C0-C10 alkyl), —C(O)(C0-C10 alkyl), —C(O)O(C0-C10 alkyl), —OC(O)(C0-C10 alkyl), —C(O)N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)C(O)(C0-C10 alkyl), —SO2N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)SO2(C0-C10 alkyl), —OCH2F, —OCHF2, —OCF3, C3-C10 cycloalkyl, C6-C10 aryl, or 4-10 membered heterocyclyl;
• L01 and L02 are linking groups each independently selected from a single bond and C1-C10 alkylidene, wherein 0-6 methylene units in the C1-C10 alkyl are optionally substituted with groups selected from -Cy-, —O—, —S—, —S—S—, —Si—, —C(O)—, —C(S)—, —C(O)O—, —OC(O)—, —OC(O)O—, —C(O)N(RL1)—, —N(RL1)C(O)—, —N(RL1)C(O)O—, —N(RL1)C(O)N(RL2)—, —N(RL1)—, —S(O)2—, —S(O)2N(RL1)—, —N(RL1)S(O)2—, —S(O)—, —S(O)N(RL1)—, —N(RL1)S(O)—, —S(O)—, —S(O)N(RL1)—, —N(RL1)S(O)—, —OP(O)(ORL1)O—, —P(O)(ORL1)O—, —P(O)—, —OP(O)N(RL1)—, —P(O)N(RL1)—, —P(O)(N(RL1RL2))—, —OP(O)(ORL1)2N(RL1)—, —P(O)(ORL1)2N(RL2)—, —N(RL1)P(O)(ORL2)O—, —N(RL1)P(O)—,
• and m2 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl is optionally substituted with one or more RL3 groups;
• each RL1 and RL2 are independently selected from a group consisting of H, D, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t4(C6-C10 aryl), —(CH2)t4(4-10 membered heterocyclyl), and —(CH2)t4(C3-C10 cycloalkyl), and t4 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, and 4-10 membered heterocyclyl is optionally substituted with a group consisting of D, halogen, cyano, nitro, azido, C1-C10 alkyl, —N(C0-C10 alkyl)(C0-C10 alkyl), —O(C0-C10 alkyl), —C(O)(C0-C10 alkyl), —C(O)O(C0-C10 alkyl), —OC(0)(C0-C10 alkyl), —C(O)N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)C(O)(C0-C10 alkyl), —SO2N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)SO2(C0-C10 alkyl), —OCH2F, —OCHF2, —OCF3, C3-C10 cycloalkyl, C6-C10 aryl, or 4-10 membered heterocyclyl;
• RL3 is selected from a group consisting of D, halogen, cyano, nitro, azido, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, —(CH2)t5(C6-C10 aryl), —(CH2)t5(4-10 membered heterocyclyl), and —(CH2)t5(C3-C10 cycloalkyl), and t5 is an integer selected from 1 to 10;
• wherein H on the C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C10 cycloalkyl, C6-C10 aryl, and 4-10 membered heterocyclyl is optionally substituted with a group consisting of D, halogen, cyano, nitro, azido, C1-C10 alkyl, —N(C0-C10 alkyl)(C0-C10 alkyl), —O(C0-C10 alkyl), —C(O)(C0-C10 alkyl), —C(O)O(C0-C10 alkyl), —OC(O)(C0-C10 alkyl), —C(O)N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)C(O)(C0-C10 alkyl), —SO2N(C0-C10 alkyl)(C0-C10 alkyl), —N(C0-C10 alkyl)SO2(C0-C10 alkyl), —OCH2F, —OCHF2, —OCF3, C3-C10 cycloalkyl, C6-C10 aryl, or 4-10 membered heterocyclyl;
• and
• each -Cy- is independently an optionally substituted divalent ring selected from:
• arylene, cycloalkylene, or heterocyclylene.