Back to results
US 2026/0217703 A1Published application
INHIBITORS OF a-HEMOL YSIN OF STAPHYLOCOCCUS AUREUS
AssigneesHelmholtz-Zentrum FüR Infektionsforschung GmbH, Lead Discovery Center GmbH
InventorsMark Brönstrup, Raffaella Dilucrezia
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel inhibitors of α-hemolysin of formula (I) and the use thereof for the prophylaxis and treatment of infections caused by Staphylococcus aureus; especially S. aureus lung infections.
Claims15
A compound of formula (I):
- wherein
- R2 is hydrogen, halogen, OH, NO2, CN or NH2;
- or a C1-4 alkyl group, a C2-4 alkenyl group, a C2-4 alkynyl group, a C3-5 cycloalkyl group, an —O—C3-5 cycloalkyl group, a C4-8 alkylcycloalkyl group, or a C1-4 heteroalkyl group;
- and
- R1 is an optionally substituted phenyl group;
- an optionally substituted naphthyl group;
- an optionally substituted heteroaryl group containing 1 or 2 rings and 5 to 10 ring atoms selected from O, S, N and C;
- an optionally substituted cycloalkyl aryl group comprising a phenyl group and a cycloalkyl group containing 5 or 6 ring atoms;
- an optionally substituted heterocycloalkyl aryl group comprising a phenyl group and a heterocycloalkyl group containing 5 or 6 ring atoms selected from O, S, B, N and C;
- an optionally substituted cycloalkyl heteroaryl group comprising a heteroaryl group comprising 5 or 6 ring atoms selected from O, S, N and C and a cycloalkyl group containing 5 or 6 ring atoms;
- or an optionally substituted heterocycloalkyl heteroaryl group comprising a heteroaryl group comprising 5 or 6 ring atoms selected from O, S, N and C and a heterocycloalkyl group containing 5 or 6 ring atoms selected from O, S, N and C;
- or an optionally substituted cycloalkyl group containing 1 or 2 rings and 3 to 10 ring atoms;
- or a solvate, a hydrate or a salt thereof.
10 more elements
A compound according to any one of the preceding claims, wherein R1 is an optionally substituted phenyl group;
- an optionally substituted naphthyl group;
- or an optionally substituted heteroaryl group containing 1 or 2 rings and 5 to 10 ring atoms selected from O, S, N and C.
Pharmaceutical composition comprising a compound according to anyone of the preceding claims and optionally one or more carrier substances and/or one or more adjuvants.
Dependencies are inferred from the claim text.