Selective bet inhibitors and uses thereof

A compound of formula (XI), or a pharmaceutically acceptable salt or N-oxide thereof:

• wherein:
• Ring A is independently selected from phenyl, 5-membered heterocyclyl and 6-membered heterocyclyl, wherein X4 is independently selected from carbon and nitrogen and X5 is independently selected from carbon and nitrogen;
• R1 is independently selected from C1-C3-alkyl, C1-C3-fluoroalkyl, C3-C4-cycloalkyl and 4-membered heterocycloalkyl;
• R2 is independently selected from C1-C4-haloalkyl, ethyl, cyano, nitro, isopropyl, tert-butyl, cyclopropyl, and SF5;
• R3 is independently selected from R3a, OR3b, and NR6R3b;
• R3a is independently selected from H, CN, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C2-C4-haloalkenyl, and C1-C3-alkylene-R3c;
• wherein R3c is independently at each occurrence selected from C3-C8-cycloalkyl, C5-C8-cycloalkenyl, 5- to 8-membered heterocycloalkenyl, 3- to 8-membered heterocycloalkyl, phenyl and 5- or 6-membered heteroaryl;
• wherein where R3c is cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, R3c is optionally substituted with from 1 to 4 R8 groups and where R3c is phenyl or heteroaryl, R3c is optionally substituted with from 1 to 5 R9 groups;
• R3b is independently selected from C1-C4-alkyl, C2-C4-alkylene-O-C1—C4-alkyl, C1-C4-haloalkyl and C1-C3-alkylene-R3d;
• wherein R3d is independently at each occurrence selected from C3-C8-cycloalkyl, 3- to 8-membered heterocycloalkyl, phenyl and 5- or 6-membered heteroaryl;
• wherein where R3d is cycloalkyl or heterocycloalkyl, R3d is optionally substituted with from 1 to 4 R8 groups and where R3d is phenyl or heteroaryl, R3d is optionally substituted with from 1 to 5 R9 groups;
• R4 is independently at each occurrence selected from ═O, ═S, halo, nitro, cyano, C0-C4-alkylene-NR5R6, C0-C4-alkylene-OR7, SR6, SOR6, C0-C4-alkylene-S(O)2R6, SO2NR6R6, C0-C4-alkylene-CO2R6, C0-C4-alkylene-C(O)R6, C0-C4-alkylene-CONR6R6, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, and C0-C4-alkylene-R4c;
• R4c is independently at each occurrence selected from C3-C6-cycloalkyl and 4- to 6-membered heterocycloalkyl;
• R5 is independently at each occurrence selected from H, C1-C4-alkyl, C(O)—C1-C4-alkyl and S(O)2—C1-C4-alkyl;
• or R5 and R6, together with the nitrogen atom to which they are attached form a C5-C8-heterocycloalkyl group optionally substituted with from 1 to 4 R8 groups;
• R6 is independently at each occurrence selected from H and C1-C4-alkyl;
• or where two R6 groups are attached to the same nitrogen, those two R6 groups together with the nitrogen atom to which they are attached optionally form a C5-C8-heterocycloalkyl group optionally substituted with from 1 to 4 R8 groups;
• R7 is independently at each occurrence selected from H, C1-C4-alkyl, C(O)—C1-C4-alkyl and C1-C4-haloalkyl;
• R8 is independently at each occurrence selected from ═O, ═S, fluoro, nitro, cyano, NR5R6, OR7, SR6, SOR6, S(O)2R6, SO2NR6R6, CO2R6, C(O)R6, CONR6R6, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl and cyclopropyl;
• R9 is independently at each occurrence selected from halo, nitro, cyano, C0-C4-alkylene-NR5R6, C0-C4-alkylene-OR7a, C0-C4-alkylene-SR6, C0-C4-alkylene-SOR6, C0-C4-alkylene-S(O)2R6, C0-C4-alkylene-SO2NR6R6, C0-C4-alkylene-CO2R6, C0-C4-alkylene-C(O)R6, C0-C4-alkylene-CONR6R6, C0-C4-alkylene-R9a, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl;
• or where two R9 groups are attached to adjacent atoms, those two R9 groups together with the atoms to which they are attached optionally form a 5- or 6-membered heterocycloalkyl group optionally substituted with from 1 to 4 R8 groups;
• R7a is independently at each occurrence selected from H, C1-C4-alkyl, C(O)—C1-C4-alkyl, C0-C4-alkylene-NR5R6, —C0-C4-alkyl-O—R7, C0-C4-alkylene-SR6, C0-C4-alkylene-SOR6, C0-C4-alkylene-S(O)2R6, C0-C4-alkylene-SO2NR6R6, C0-C4-alkylene-CO2R6, C0-C4-alkylene-C(O)R6, C0-C4-alkylene-CONR6R6 and C1-C4-haloalkyl;
• R9a is independently at each occurrence selected from C3-C6-cycloalkyl and 4- to 6-membered heterocycloalkyl;
• R10 is independently at each occurrence selected from halo, C1-C4-alkyl, C1-C4-haloalkyl, nitro, cyano, NR5R6, OR7, SR6, SOR6, S(O)2R6, SO2NR6R6, CO2R6, C(O)R6, CONR6R6, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl and 4-membered heterocycloalkyl;
• Rx and Ry are each independently selected from H, halo, nitro, cyano, NR5R6, OR7, SR6, SOR6, S(O)2R6, SO2NR6R6, CO2R6, C(O)R6, CONR6R6, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C3-C4-cycloalkyl and 4-membered heterocycloalkyl;
• m is an integer selected from 0, 1, 2, 3 and 4;
• n17 is an integer selected from 0, 1 and 2;
• wherein any of the aforementioned alkyl, alkylene, alkenyl, cycloalkyl or heterocycloalkyl groups is optionally substituted, where chemically possible, by 1 to 5 substituents which are each independently at each occurrence selected from the group consisting of:
• C1-C4-alkyl, oxo, fluoro, nitro, cyano, NRaRb, ORa, SRa, CO2Ra, C(O)Ra, CONRaRa, S(O)Ra and S(O)2Ra;
• wherein Ra is independently at each occurrence selected from H, C1-C4-alkyl and C1-C4-haloalkyl;
• and Rb is independently at each occurrence selected from H, C1-C4-alkyl, C(O)—C1-C4-alkyl and S(O)2—C1-C4-alkyl.