Kinesin kif18a inhibitor and use thereof

A compound having a structure of formula (II), or pharmaceutically acceptable salts, stereoisomers, isotope isomers, prodrugs, hydrates, or solvates of the compound:

• wherein, W1 represents C;
• wherein, W2 represents CH or N;
• wherein, Z represents
• wherein L1 represents —C(O)NH—, —HNC(O)—, or 5-6 membered heteroaryl
• wherein, L2 represents absence or —C1-C6 alkylene;
• wherein, R1 represents L3-R3;
• wherein, L3 represents —NRaSO2—;
• wherein, R3 represents C1-C6 alkyl, wherein the C1-C6 alkyl is optionally independently substituted with 0-3 substituents selected from halogen and —ORa;
• wherein, Cy1 represents 6-12-membered aryl or 5-12-membered heteroaryl;
• the Cy1 is optionally substituted with 0-3 substituents selected from the following:
• halogen, C1-C6 alkyl, C1-C6 haloalkyl, hydroxy(C1-C6 alkyl), ORa, —O—(C1-C6 haloalkyl), 5-6-membered heteroaryl, phenyl, —SRa, —SF5, cyano, nitro, —NRaRb, —NRaC(O)Rb, —C(O)NRaRb, —OC(O)Ra, —C(O)Ra, —P(O)RaR, —C(O)ORa, —S(O)Ra, —S(O)2Ra, and —S(O)2NRaRb;
• wherein, Cy2 represents a 3-12-membered saturated or unsaturated monocyclic or bicyclic ring, the 3-12-membered saturated or unsaturated monocyclic or bicyclic ring optionally contains 0-3 heteroatoms selected from O, N, and S;
• the Cy2 is optionally substituted with 0-3 substituents selected from the following:
• halogen, C1-C6 haloalkyl, C1-C6 haloalkyl, hydroxy (C1-C6 alkyl), —ORa, —O—(C1-C6 haloalkyl), —SR, —SF5, cyano, nitro, —NRaRb, —NRaC(O)Rb, —C(O)NRaRb, —OC(O)Ra, —C(O)ORa, —S(O)Ra, —S(O)2Ra, and —S(O)2NRaR;
• wherein, ring A represents a saturated or unsaturated 4-12-membered ring, preferably a 5-12-membered ring;
• the saturated or unsaturated 4-12-membered ring optionally contains 0-3 heteroatoms selected from O, N, and S;
• the ring A is optionally substituted with 0-3 substituents selected from the following:
• halogen, C1-C6 alkyl, C1-C6 haloalkyl, hydroxy C1-C6 alkyl, —ORa, —O—C1-C6 haloalkyl, —SRa, —SF5, cyano, nitro, —NRaRb, —NRaC(O)Rb, —C(O)NRaR, —OC(O)Ra, —C(O)ORa, —S(O)Ra, —S(O)2Ra, and —S(O)2NRaRb;
• wherein, Ra, Rb each independently represent hydrogen, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 haloalkyl, or hydroxy (C1-C6 alkyl);
• or Ra and Rb, together with an atom attaching to the Ra and the Rb, form a 3-6-membered saturated or unsaturated ring wherein the 3-6-membered saturated or unsaturated ring optionally contains 0-2 heteroatoms selected from O, S, and N;
• wherein, m represents integers from 0 to 3.