Compounds comprising heteroaryl rings and compositions and methods thereof

A compound, wherein the compound has the structure of formula I:

• or a salt thereof, wherein:
• Ring A is an optionally substituted 5-6 membered aromatic ring having 0-4 heteroatoms, or is
• each of X1, X2a, X2b, and X2c is independently —N═, —C(R2)═ or optionally substituted —CH═;
• X1a is —O—, —S—, —N(R′)—, —C(R′)2—, or optionally substituted —CH2— or —NH—;
• X3 is —O—, —S—, —Se—, —N(R′)— or optionally substituted —NH—;
• each of X4, X5, X6, X7 and X8 is independently —N═, —C(R6)═ or optionally substituted —CH═;
• each of R1, R2, Rs and R6 is independently halogen, —CN, —NO2, -L-R′, —OR′, —N(R′)2, —N(R′)C(O)OR′, —C(O)R′, —C(O)OR′, —C(O)N(R′)2, or —OC(O)N(R′)2;
• L1 is a covalent bond, —C(O)—, —C(S)—, —S(O)2—, —N(R′)C(O)—, —N(R′)S(O)2—, —N(R′)C(S)— or
• each of R3, R4 and R5 is independently R′;
• each of L and L2 is independently optionally substituted C1-3 alkylene, wherein one or more methylene units of the alkylene are optionally and independently replaced with —O—, —S—, —C(R4)(R5)—, —N(R4)—, optionally substituted —CH═N—, optionally substituted —CH═CH— or -Cy-;
• each -Cy- is independently wherein Ring B is an optionally substituted saturated or partially saturated 3-10 membered ring having 0-4 heteroatoms;
• t is 0, 1, 2, 3 or 4;
• each R′ is independently R, —OR, —C(O)R, —C(O)OR, or —S(O)2R;
• each R is independently hydrogen or an optionally substituted group selected from C1-C10 aliphatic, C1-C10 heteroaliphatic having 1-3 heteroatoms, 3-10 membered cycloaliphatic, 3-10 membered heterocyclyl having 1-4 heteroatoms, 6-10 membered aryl, 5-10 membered heteroaryl having 1-6 heteroatoms, 6-10 membered aryl-C1-C10 aliphatic, and 5-10 membered heteroaryl having 1-6 heteroatoms-C1-C10 aliphatic;
• or
• two R groups on the same atom are optionally and independently taken together with the atom to form an optionally substituted 3-10 membered ring having, in addition to the atom, 0-4 heteroatoms;
• or
• two R groups on two atoms are optionally and independently taken together with their intervening atoms to form an optionally substituted 3-10 membered ring having, in addition to the intervening atoms, 0-4 heteroatoms.