N-Myristoyltransferase Inhibitors And Methods Of Use

A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• A is an optionally fused 6-membered aryl or heteroaryl ring, which is optionally substituted by at least one substituent selected from the group consisting of F, Cl, Br, I, OR, OC(O)N(R)2, CN, NO, NO2, ONO2, CF3, OCF3, R, N(R)2, SR, SOR, SO2R, SO2N(R)2, SO3R, C(O)R, C(O)C(O)R, C(O)CH2C(O)R, C(S)R, C(O)OR, OC(O)R, and C(O)N(R)2;
• X is C, CH, or N, provided that if A is present then X is C;
• Z is CH or N;
• Y is CH or N;
• R1 is selected from the group consisting of hydrogen, F, Cl, and Br;
• L is O, NR, or ═N—*, wherein the bond with * is attached to the aryl ring;
• T is —C1-6 alkyl-C5-6 heteroaryl, wherein the C5-6 heteroaryl is optionally substituted with at least one selected from the group consisting of F, Cl, Br, I, OR, OC(O)N(R)2, CN, NO, NO2, ONO2, CF3, OCF3, R, N(R)2, SR, SOR, SO2R, SO2N(R)2, SO3R, C(O)R, C(O)C(O)R, C(O)CH2C(O)R, C(S)R, C(O)OR, OC(O)R, and C(O)N(R)2;
• V is —C0-6 alkyl-C5-6 heterocyclyl, —O—C0-6 alkyl-C5-6 heterocyclyl, —C0-6 alkyl-NR2, or —O—C2-6 alkyl-NR2, wherein the C5-6 heterocyclyl is optionally substituted with at least one selected from the group consisting of F, Cl, Br, I, OR, OC(O)N(R)2, CN, NO, NO2, ONO2, CF3, OCF3, R, N(R)2, SR, SOR, SO2R, SO2N(R)2, SO3R, C(O)R, C(O)C(O)R, C(O)CH2C(O)R, C(S)R, C(O)OR, OC(O)R, and C(O)N(R)2;
• R is independently at each occurrence selected from the group consisting of hydrogen or optionally substituted C1-12 alkyl;
• R2 is independently at each occurrence selected from the group consisting of F, Cl, Br, I, OR, OC(O)N(R)2, CN, NO, NO2, ONO2, CF3, OCF3, R, N(R)2, SR, SOR, SO2R, SO2N(R)2, SO3R, C(O)R, C(O)C(O)R, C(O)CH2C(O)R, C(S)R, C(O)OR, OC(O)R, and C(O)N(R)2;
• R3 is independently at each occurrence selected from the group consisting of F, Cl, Br, I, OR, OC(O)N(R)2, CN, NO, NO2, ONO2, CF3, OCF3, R, N(R)2, SR, SOR, SO2R, SO2N(R)2, SO3R, C(O)R, C(O)C(O)R, C(O)CH2C(O)R, C(S)R, C(O)OR, OC(O)R, and C(O)N(R)2;
• m is 0, 1, 2, or 3;
• and
• n is 0, 1, 2, 3, or 4.