Pyridazinone heterocyclic compound myosin ii inhibitor and use thereof

A compound represented by formula (I), a stereoisomer, a deuterated substance, a solvate, or a pharmaceutically acceptable salt or a eutectic crystal thereof,

• wherein
• each of R1, R2 and R3 is independently selected from H, deuterium, RA1, —O-haloC1-4 alkyl, —NH-haloC1-4 alkyl, —OC1-4 alkyl, C1-6 alkoxy, halogen, cyano, nitro, C1-4 alkyl, —NH—C1-4 alkyl, —N(C1-4 alkyl)2, —NH—C3-10 cycloalkyl, —NHC(O)C1-4 alkyl, or 4- to 10-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, and S, and the alkyl, alkoxy, cycloalkyl, or heterocycloalkyl is optionally further substituted with 1 to 3 groups selected from halogen, D, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy, C3-10 cycloalkyl, 4- to 6-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, or S, phenyl, and NH2, provided that R1, R2 and R3 are not simultaneously selected from H;
• RA1 is selected from haloC2-6 alkenyl, C2-4 alkynyl, —O—(CH2)r—Ra, C3-10 cycloalkyl, 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, or S, —C1-4 alkyl-Ra, —C1-4 alkyl-ORa, —C1-4 alkyl-NRbRa, —NRb—S(O)2—Ra, —NRb—S(O)2—NRbRa, —O—NRbRa, —NH—ORb, or —Se—(CH2)r—Ra, and the alkynyl, heteroaryl, alkyl, or cycloalkyl is optionally further substituted with 1 to 3 groups selected from halogen, deuterium, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy and NH2;
• each Ra is selected from CN, haloC1-6 alkyl, C3-10 cycloalkyl, 4- to 10-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, or S, 6- to 10-membered aryl, 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, or S, or —C(O)—Ra1, and the alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally further substituted with 1 to 3 groups selected from halogen, ═O, deuterium, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy and NH2;
• each Rb is selected from H, deuterium, C1-4 alkyl, C3-4 cycloalkyl, haloC1-4 alkyl, or deuterated C1-4 alkyl;
• Ra1 is selected from OH, NH2, —NHC1-4 alkyl, —N(C1-4 alkyl)2, —NHC3-10 cycloalkyl, C1-4 alkoxy, C1-6 alkyl, C3-10 cycloalkyl, 6- to 10-membered aryl, 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, or S;
• X is selected from CR10 or N;
• X1 is selected from 0 or S;
• each of R4 and R5 is independently selected from H, deuterium, C3-10 cycloalkyl, C2-4 alkenyl, C2-6 alkynyl, halogen, amino, —NH—C1-4 alkyl, —N(C1-4 alkyl)2, C1-4 alkyl, haloC1-4 alkyl, 4- to 10-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, or S, 5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, or S, or 6- to 10-membered aryl;
• each of R6, R7, R8, R9, and R10 is independently selected from H, deuterium, RA2, halogen, OH, CN, amino, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, haloC1-4 alkyl, —NH—C1-4 alkyl, —N(C1-4 alkyl)2, —S(O)Rc, —S(O)2Rc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)2, or —OC(O)Rc, and the alkyl, alkenyl, alkynyl, or alkoxy is optionally further substituted with 1 to 3 groups selected from halogen, deuterium, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy and NH2;
• RA2 is selected from —(CH2)r—(C3-10 cycloalkyl), —(CH2)r-(4- to 10-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, S, or Si), or —(CH2)r-(5- to 10-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, or S), —P(O)(Rc)2, —Si(Rc)3, —SF5, N3, B(OH)2, or —S(O)(═NH)Rc, and the cycloalkyl, heterocycloalkyl, or heteroaryl is optionally further substituted with 1 to 3 groups selected from halogen, ═O, D, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, C3-6 cycloalkyl, 4- to 7-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, or S, deuterated C1-4 alkoxy and NH2;
• each Rc is independently selected from H, OH, C1-4 alkyl, C3-7 cycloalkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy, or NH2;
• each r is independently selected from 0, 1, 2 or 3;
• L1 is selected from a bond, O, NH, S, —CD2-, —CHD-, —CRL1RL2, C1-4 alkyl, —C(O)—, S(O), or S(O)2, and the alkyl is optionally further substituted with RL1;
• L2 is selected from a bond, O, NH, S, —CH2—, —CD2-, —CHD-, —CRL1RL2—, —CHRL—, —CDR2—, C2-4 alkyl, —C(O)—, S(O), or S(O)2, and the alkyl is optionally further substituted with 1 to 3 RL1;
• each of RL1 and RL2 is independently selected from halogen, OH, CN, amino, C1-4 alkyl, C1-4 alkoxy, Cm cycloalkyl, or 4- to 6-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, or S;
• alternatively, R2, R4 and L1 together with the atoms to which they are attached form a 5- to 7-membered carbocyclic ring, or a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from N, O, or S, and the carbocyclic ring or heterocyclic ring is optionally further substituted with 1 to 3 groups selected from RA3;
• alternatively, R4 and R5 together with the atoms to which they are attached form a 5- to 7-membered monocyclic carbocyclic ring, or a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from N, O, or S, and the carbocyclic ring or heterocyclic ring is optionally substituted with 1 to 3 groups selected from RA3;
• alternatively, RL2 and R9 together with the atoms to which they are attached form a 5- to 7-membered carbocyclic ring, or a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from N, O, or S, and the carbocyclic ring or heterocyclic ring is optionally further substituted with 1 to 3 groups selected from RA3;
• each RA3 is independently selected from ═O, halogen, deuterium, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy and NH2;
• provided that:
• one of the combinations of R6 and R10, R10 and R7, R7 and R8, and R8 and R9 together with the atoms to which they are attached form a 4- to 8-membered carbocyclic ring or 5- to 7-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, S, B, or Si, and the carbocyclic ring or heterocycloalkyl is optionally further substituted with 1 to 3 groups selected from ═O,
• halogen, deuterium, CN, OH, C1-4 alkyl, haloC1-4 alkyl, deuterated C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, deuterated C1-4 alkoxy, 5- to 7-membered heterocycloalkyl containing 1 to 3 heteroatoms selected from N, O, S, B, or Si, and 5- to 7-membered heteroaryl containing 1 to 3 heteroatoms selected from N, O, S, B, or Si and NH2.