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US 2026/0217676 A1Published application
Crystalline forms of n-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide
AssigneeAgios Pharmaceuticals, Inc.
InventorsJose Luis Rios Lizarraga, Eric Simone, Jacob P. Sizemore, Shijie Zhang, Jeffrey D. Wilson, Liting Guo, Mahmoud Mirmehrabi, Yeqing Su
Life of this patent
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Abstract
Provided herein are amorphous and crystalline hemisulfate salt forms of the formula. Also provided are pharmaceutical compositions comprising the amorphous and crystalline hemisulfate salt forms, methods for their manufacture, and uses thereof for treating conditions associated with pyruvate kinase such as e.g., pyruvate kinase deficiency.
Claims22
A pharmaceutical composition comprising the amorphous form of a compound having the formula:
- and a pharmaceutically acceptable carrier selected from one or more of microcrystalline cellulose, mannitol, Croscarmellose Sodium, and Sodium Stearyl Fumarate.
A crystalline form of a compound having the formula:
- wherein the crystalline form is crystalline Form B, crystalline Form C, crystalline Form D, crystalline Form E, crystalline Form F, crystalline Form G, crystalline Form H, crystalline Form I, or crystalline Form J.
Dependencies are inferred from the claim text.