Compound as irak inhibitor

A compound of formula I, or a cis-trans isomer, an optical isomer, a racemate, a pharmaceutically acceptable salt, a prodrug, a deuterated derivative, a hydrate thereof or a solvate thereof:

• wherein in the formula I:
• Z1 is selected from substituted or unsubstituted C3-C12 cycloalkylenyl, and substituted or unsubstituted 3-12 membered heterocycloalkylenyl;
• Z2 is selected from a chemical bond (absent), substituted or unsubstituted C1-C6 alkylenyl, substituted or unsubstituted C2-C6 alkenylenyl, and substituted or unsubstituted C2-C6 alkynylenyl;
• each R1 is independently selected from hydroxyl, thiol, carboxyl, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C1-C12 hydroxyalkyl, substituted or unsubstituted C1-C12 thiolalkyl, substituted or unsubstituted C1-C12 aminoalkyl, substituted or unsubstituted C3-C12 hydroxycycloalkyl, substituted or unsubstituted C3-C12 thiolcycloalkyl, substituted or unsubstituted C3-C12 aminocycloalkyl, substituted or unsubstituted C1-C12 alkoxy, substituted or unsubstituted C1-C12 alkylthio, —N(R5)R6, substituted or unsubstituted C1-C8 carboxyl, substituted or unsubstituted C2-C8 acyl, substituted or unsubstituted C2-C8 ester group, and halogen;
• R2 and R3 are each independently selected from a chemical bond, substituted or unsubstituted C1-C10 alkyl, substituted C3-C10 cycloalkyl, halogen, C1-C10 haloalkyl, C1-C12 hydroxyalkyl, cyano, nitro, -A-R7, —N(R5)R6, substituted or unsubstituted C6-C12 aryl, and substituted or unsubstituted 5-12 membered heteroaryl;
• R5 and R6 are each independently selected from hydrogen, substituted or unsubstituted C1-C10 alkyl, and substituted or unsubstituted C3-C8 cycloalkyl;
• A is selected from a chemical bond, S and O;
• R7 is selected from hydrogen, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C10 alkenylenyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted 3-12 membered heterocycloalkyl, substituted or unsubstituted 5-20 membered heteroaryl, and —R8-R9;
• R8 is selected from a chemical bond, substituted or unsubstituted C1-C6 alkylenyl, and substituted or unsubstituted C2-C6 alkenylenyl;
• R9 is selected from substituted or unsubstituted C3-C12 cycloalkyl, and substituted or unsubstituted C3-C12 heterocycloalkyl;
• Z3 is selected from carbonyl,
• R4 is selected from substituted or unsubstituted C6-C20 aryl, and substituted or unsubstituted 5-20 membered heteroaryl;
• wherein each of the “substituted” means that one, two or more (preferably 1, 2, 3 or 4) hydrogen atoms on the group are substituted by a substituent selected from:
• C1-C12 hydroxyalkyl, C2-C8 acyl, C3-C8 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, hydroxyl, thiol, amino, nitro, halogen, 3-12 membered heterocycloalkyl, cyano, C1-C10 haloalkyl, C3-C8 halocycloalkyl, C2-C4 ester group, C2-C4 acylamino, C1-C4 carboxyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C12 aryl, and 5-12 membered heteroaryl;
• and
• the heterocycloalkylenyl, heterocycloalkyl and heteroaryl each independently comprises 1-3 (preferably 1, 2 or 3) heteroatoms selected from N, O and S;
• a is selected from 1, 2, 3 and 4;
• b is selected from 0, 1, 2 and 3;
• and
• c is selected from 0 and 1.