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US 2026/0217674 A1Published application
New acetylcholinesterase inhibitors and uses thereof for preventing and treating compulsive disorders and neurodegenerative disorders
AssigneesUniversite De Mcgill, Sorbonne Universite, Centre National de la Recherche Scientifique (CNRS)
InventorsSalah EL MESTIKAWY, Nicolas Pietrancosta, Mathieu FAVIER
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Abstract
The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt and/or solvate thereof. The present invention also relates to the use of the compound of formula (I) as a drug, in particular for preventing or treating compulsive disorders and related behaviors, including addiction, obsessive-compulsive disorders and eating disorders, and neurodegenerative disorders such as Parkinson's disease or Alzheimer's disease.
Claims21
A compound of formula (I):
- or a pharmaceutically acceptable salt and/or solvate thereof,
- in which
- represents a single or a double bond, and
- X is an oxygen atom or a group N—OH,
- R1 and R2 are each independently H, an optionally substituted nitrogen-containing heterocyclyl group, an optionally substituted C1-C6 aliphatic chain or an optionally substituted aryl, wherein up to 4 methylene units of the C1-C6 aliphatic chain are optionally replaced by 0, C(O), NH or N—C1-C6alkyl, provided that at least one of R1 and R2 is an optionally substituted nitrogen-containing heterocyclyl group,
- L1 and L2 are each independently a divalent radical derived from a C1-C12 aliphatic chain, wherein one or more methylene unit(s) are optionally replaced by arylene, —O—, —S—, —C(═O)—, —SO2— or —N(C1-C6 alkyl)-, wherein the C1-C12 aliphatic chain is optionally substituted,
- p and n are each independently 0 or 1, provided that p is 1 when R1 is an optionally substituted nitrogen-containing heterocyclyl group and n is 1 when R2 is an optionally substituted nitrogen-containing heterocyclyl group, and
- R′ is H, halogen, an optionally substituted C1-C6 aliphatic chain, an optionally substituted aryl, an optionally substituted heteroaryl or an optionally substituted C1-C6 alkyl-aryl, wherein up to 4 methylene units of the C1-C6 aliphatic chain are optionally replaced by O, C(O), NH or N—C1-C6alkyl.
5 more elements
14-15. (canceled)
Dependencies are inferred from the claim text.