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US 2026/0217673 A1Published application
Novel compound as ron inhibitor
AssigneeLG Chem, Ltd.
InventorsYoung Jin HAM, Joong Heui CHO, Jung Joon KIM, Hong Bin YOON, Young Shin KWAK, Woo Sook KIM, Sung Woong JANG
Life of this patent
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Abstract
The present invention relates to a novel compound as a protein kinase inhibitor, particularly a RON inhibitor.
Claims8
A compound represented by Chemical Formula 1 below, or a pharmaceutically acceptable salt thereof:
- in Chemical Formula 1,
- X is N or C;
- R1 is any one selected from the group consisting of hydrogen, a halogen, a substituted or unsubstituted alkyl, and a substituted or unsubstituted cycloalkyl;
- R2 is any one selected from the group consisting of hydrogen and a substituted or unsubstituted alkyl;
- Y1 and Y2 are each independently any one selected from the group consisting of hydrogen, a halogen, a substituted or unsubstituted alkyl, and a substituted or unsubstituted cycloalkyl;
- Z is any one selected from the group consisting of hydrogen, a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a nitro, a cyano, and —(CH2)n—W, wherein n is an integer from 0 to 3, W is —NRaRb, —ORa or a heterocycloalkyl, wherein Ra and Rb are each independently hydrogen or a substituted or unsubstituted alkyl;
- A is any one selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, and a substituted and unsubstituted heteroaryl;
- and
- the substituted functional groups are groups substituted with at least one selected from the group consisting of a halogen, an alkyl, a hydroxyalkyl, a hydroxy, an alkoxy, an haloalkyl, an alkoxyalkyl, —(CO)—(CH2)n—ORc, and an aryl, wherein n is an integer from 0 to 3, and Rc is hydrogen or an alkyl.
6 more elements
Dependencies are inferred from the claim text.