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US 2026/0217671 A1Published application
Compound for preventing and/or treating neurodegenerative disease
AssigneeTyk Medicines, Inc.
InventorsApeng LIANG, Jian ZHU, Yusheng WU, Shaoqing CHEN, Jun LI, Jiaying LIN
Life of this patent
Estimating the term…
Abstract
A compound can prevent and/or treat a neurodegenerative disease. Specifically, the compound has a structure as shown in formula I. A preparation method for the compound and a use of the compound in preventing and/or treating a neurodegenerative disease are provided.
Claims10
A compound, wherein the compound is a compound of formula I, or a stereoisomer, a racemate, or a pharmaceutically acceptable salt thereof,
- wherein,
- Ring A is selected from the group consisting of
- X1 is selected from the group consisting of O, S, NH, and NR;
- X2 is selected from the group consisting of O, NH, and NR;
- R1 is selected from the group consisting of
- R2 is selected from the group consisting of H, halogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C3-C6 cycloalkyl;
- R3 and R4 are independently selected from the group consisting of H, D, halogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C3-C6 cycloalkyl, or R;
- and R4 together with the carbon to which they are attached form a substituted or unsubstituted 3-7 membered cycloalkyl or a substituted or unsubstituted 3-7 membered heterocyclyl containing one or more heteroatoms selected from O, S and N;
- each R5, R6, R7, R5, R9, and R10 is independently selected from the group consisting of H, D, halogen, trifluoromethyl, cyano, hydroxy, amino, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C1-C6 alkyl-NR16—, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C3-C6 cycloalkoxy, and substituted or unsubstituted C3-C6 cycloalkyl-NR16—;
- each R11, R12, R13, R14, and R15 is independently selected from the group consisting of H, D, halogen, trifluoromethyl, cyano, hydroxy, amino, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C1-C6 alkyl-NR16, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C3-C6 cycloalkoxy, and substituted or unsubstituted C3-C6 cycloalkyl-NR16—;
- each R17 and R15 is independently selected from the group consisting of H, D, C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl and C3-C6 cycloalkoxy;
- or R17 and R18 together with the carbon to which they are attached form a substituted or unsubstituted 3-7 membered cycloalkyl or a substituted or unsubstituted 3-7 membered heterocyclyl containing one or more heteroatoms selected from O, S and N,
- each R is independently a substituted or unsubstituted C1-C6 alkyl;
- the “substituted” each independently refers to be substituted by one or more substituents selected from the group consisting of D, halogen, trifluoromethyl, cyano, hydroxy, amino, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkyl-NR16—, C3-C6 cycloalkyl, C3-C6 cycloalkoxy, and C3-C6 cycloalkyl-NR16—;
- each R16 is independently selected from the group consisting of H and C1-C6 alkyl;
- the premise is that when X1 is NH, X2 is O, and R3, R4, R17 and R18 are H, ring A is not
13 more elements
Dependencies are inferred from the claim text.