Inhibitors of activin receptor type i (acvri) and activin receptor like type i (acvrli), and methods using same

A compound of Formula (I), or a salt, solvate, stereoisomer, or isotopologue thereof:

• wherein:
• R1 is selected from the group consisting of optionally substituted C6-C10 aryl and optionally substituted C2-C12 heteroaryl;
• R2 is selected from the group consisting of H and optionally substituted C3-C8 cycloalkyl;
• R3a is selected from the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C7-C13 aralkyl, and
• R3b is H,
• or R3a and R3b can combine with the nitrogen to which they are bound to form an optionally substituted C2-C12 heterocycloalkyl;
• R4a, R4b, and R4c are each independently selected from the group consisting of H, halogen, CN, NO2, optionally substituted C1-C6 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C2-C6 heterocycloalkyl, optionally substituted C7-C12 aralkyl, optionally substituted C6-C10 aryl, and optionally substituted C2-C12 heteroaryl;
• L is selected from the group consisting of (optionally substituted C1-C6 alkylenyl)-*, -(optionally substituted C3-C6 cycloalkylenyl)-*, -(optionally substituted C1-C6 alkylenyl)C(═O)—*, -(optionally substituted C3-C6 cycloalkylenyl)C(═O)—*, —C(═O)(optionally substituted C1-C6 alkylenyl)-*, and —C(═O)(optionally substituted C3-C6 cycloalkylenyl)-*;
• A is optionally substituted C2-C12 heterocyloalkylenyl;
• B is selected from the group consisting of optionally substituted C1-C6 alkyl, optionally substituted C3-C12 cycloalkyl, optionally substituted C7-C13 aralkyl, optionally substituted C6-C10 aryl, optionally substituted C2-C12 heteroaryl, C(═O)(optionally substituted C1-C6 alkyl), C(═O)(optionally substituted C3-C12 cycloalkyl), C(═O)(optionally substituted C7-C13 aralkyl), C(═O)(optionally substituted C6-C10 aryl), and C(═O)(optionally substituted C2-C12 heteroaryl);
• and
• * indicates a bond between L and A.