Compounds, compositions and uses thereof in the treatment and prevention of diseases and conditions associate with or aggravated by impaired mitophagy or oxidative stress

A compound having a general formula (I)

• wherein each of R1 and R2 is independently selected from —C(═NR3)NR4R5, —NR6R7, —N+R8R9R10, —NR11C(═N)NR12R13, —NR18NR19R20, —NR14C(═N)—NR15—C(═N)—NR16R17=N—R21,
• wherein
• each of R3-R32 is independently selected from H, straight or branched C1-C12 alkyl, straight or branched C2-C12 alkenyl, straight or branched C2-C12 alkynyl, phenyl, —OH and any combinations thereof;
• each of L1 and L2 is independently selected from straight or branched C4-C12 alkylene, straight or branched C4-C12 alkenylene, straight or branched C4-C12 alkynylene;
• each L1 and L2 is independently optionally interrupted by at least one of C4-C8 cycloalkylene, C4-C8 cycloalkenylene, C4-C8 cycloalkynylene, arylene, heteroarylene, heteroatom and any combinations thereof;
• each of L1 and L2 is independently optionally substituted with at least one of halogen and any combinations thereof;
• each of X1 and X2 is independently selected from null, —O—, —S—, —S(═O)—, —S(═O)2—;
• each of Z1-Z7 is independently a halogen;
• wherein n is independently an integer selected from 0-8;
• each of X3—X6 is independently selected from H, halogen, astatine, tennessine and any combinations thereof.