Pyrazolidine-3, 5-dione based compounds and a process for preparation thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsSantosh Baburao MHASKE, Priyanka HALDER
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Abstract
The present invention relates to 5,6-diaryl-5,6-diazaspiro [2.4]heptane-4,7-dione compound of formula (I) and the process of preparation thereof. The present invention also relates to the compound of formula (I) and its use in the preparation of sulfinpyrazone uricosuric drug or its derivatives/analogues. The compound of formula (I) is useful as anti-malarial, anti-microbial, anti-bacterial, anti-inflammatory, COX-2 inhibition, and anti-analgesics agents.
Claims10
A 5,6-diaryl-5,6-diazaspiro [2.4]heptane-4,7-dione compound of formula (I)
- wherein
- R1 and R2 may be same or different, having substituents selected from the group consisting of hydrogen, substituted or unsubstituted (C6-C10)aryl, substituted or unsubstituted (C2-C6)alkyl, substituted or unsubstituted heterocyclyl, —(CH2)-substituted or unsubstituted (C6-C10)aryl, substituted or unsubstituted (C3-C10)alkene, substituted or unsubstituted (C3-C10)alkyne, ferrocene, and substituted or unsubstituted (C1-C6)alkoxy.
A process of preparation of 5,6-diaryl-5,6-diazaspiro [2.4]heptane-4,7-dione compound of formula (I) comprising the steps of:
- (a) reacting a compound of formula (3) with thionyl chloride under reflux to obtain an unstable dichloride compound of formula (3′), which was further reacted with aromatic/aliphatic amine compound of formula R1/R2—NH2 in presence of a base and a solvent to obtain diamide compound of formula (4);
- and
- wherein R1 and R2 are the same as defined above;
- (b) reacting the compound of formula (4) with an oxidant in presence of a solvent under stirring to obtain a compound of formula (I).
(canceled)
Dependencies are inferred from the claim text.