Compounds Affecting KRAS

A compound having the general formula I

• wherein R1 is selected from H, branched, cyclo or linear (C1-C6)-alkyl, branched, cyclo or linear (C1-C6)-alkyl-OH, branched, cyclo or linear (C1-C6)-alkyl-NH2, branched or linear (C1-C6)-alkyl comprising a secondary or tertiary amine or an ether group;
• R2 is selected from branched, cyclo or linear (C1-C6)-alkyl, heterocyclyl, substituted or unsubstituted (C6-C10)-aryl, or substituted or unsubstituted (C5-C5)-cycloalkenyl, wherein the substituted (C6-C10)-aryl or substituted (C5-C5)-cycloalkenyl is substituted with 1 or 2 groups selected from the groups consisting of
• a) OCH3,
• b) halogen,
• c) a substituent having formula II
• wherein “1” is selected from 0 to 6, “m” is 1 or 2, the aryl group has 5 to 10 atoms, and
• wherein R6 is H, branched, cyclo or linear (C1-C6)-alkyl, or halogen;
• d) a substituent having formula III
• wherein the aryl groups independently have 5 to 10 atoms, and “n”, “o” and “p” are independently selected from 0 to 6;
• and/or
• e) a substituent having formula IV
• wherein “q” and “r” are independently selected from 0 to 6, the aryl group has 5 to 10 atoms, and wherein R7 is selected from halogen, NO2, NH2, CN, CF3, and branched, cyclo or linear (C1-C6)-alkyl;
• wherein R7 cannot be Cl, when the substituent of formula IV is the only substituent of the (C6-C10)-aryl and “q” is 0 and “r” is 1;
• R3 is independently selected from H, branched, cyclo or linear (C1-C6)-alkyl, branched, cyclo or linear (C1-C6)-alkyl-OH, CF3, halogen, NO2, and CN;
• R4 is independently selected from H, OH, O, NH2, and NO2;
• and
• R5 is independently selected from N, NH, O, S, branched, cyclo or linear (C1-C6)-alkyl, branched or linear (C1-C6)-alkyl comprising a secondary or tertiary amine, an ether group or a sulfide group, N═N, and CH═N.