Phenyl-substituted heteroaryl compound and pharmaceutical composition comprising same, preparation method therefor and use thereof

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,

• wherein
• ring A is phenyl or 5- to 6-membered heteroaryl;
• each R1 is the same or different, and independently selected from the group consisting of H, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, cyano, hydroxyl, amino, nitro, and 3- to 8-membered cycloalkyl;
• R2 is selected from the group consisting of H, halogen, and C1-6 alkyl;
• R3 is selected from the group consisting of H, halogen, C1-6 alkyl, and C1-6 haloalkyl;
• R4 is selected from the group consisting of H, halogen, cyano, hydroxyl, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, and 3- to 8-membered cycloalkyl;
• R5 is selected from the group consisting of H, halogen, and C1-6 alkyl;
• each R6 is the same or different, and independently selected from the group consisting of H, halogen, cyano, hydroxyl, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, —C(O)ORe, —C(O)NRgRh, —C(O), —S(O)2Rf, and 3- to 8-membered cycloalkyl;
• R7 is selected from the group consisting of H, halogen,
• —C(O)ORe, —C(O)NRgRh, —C(O)Rf, and —S(O)2Rf;
• RA and RB are the same or different, and each independently selected from the group consisting of H, C1-6 alkyl, or C1-6 haloalkyl;
• R7a and R7b are the same or different, and each independently selected from the group consisting of H, D, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, —C(O)ORe, —C(O)NRgRh, —C(O)f, —S(O)2Rf, and 3- to 8-membered cycloalkyl;
• alternatively, R7a and R7h together with the carbon to which they are attached form a 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl ring, wherein the 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of halogen and C1-6 alkyl;
• R7c and R7d are the same or different, and each independently selected from the group consisting of H, D, halogen, cyano, hydroxyl, amino, oxo (═O), C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, and 3- to 8-membered cycloalkyl;
• alternatively, R7c and R7d together with the carbon to which they are attached form a 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl ring, wherein the 3- to 8-membered cycloalkyl or 3- to 8-membered heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of halogen and C1-6 alkyl;
• Re is selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, and 3- to 8-membered cycloalkyl;
• Rg and Rh are the same or different, and each independently selected from the group consisting of H, C1-6 alkyl, hydroxyl, C1-6 alkoxy, and 3- to 8-membered cycloalkyl, wherein the C1-6 alkyl, C1-6 alkoxy, and 3- to 8-membered cycloalkyl are optionally substituted by one or more substituents selected from the group consisting of halogen, cyano, hydroxyl, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 hydroxyalkyl, and 3- to 8-membered cycloalkyl;
• alternatively, Rg and Rh together with the N to which they are attached form a 3- to 6-membered heterocyclyl ring, wherein the 3- to 6-membered heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, and C1-6 haloalkyl;
• Rf is selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, and 3- to 8-membered cycloalkyl;
• alternatively, R6 and R7 together with the atom to which they are attached form a 3- to 8-membered heterocyclyl ring, wherein the 3- to 8-membered heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of hydroxyl, oxo, C1-6 alkoxy, C1-6 alkyl, C1-6 haloalkyl, and C1-6 haloalkoxy;
• R8 and R9 are the same or different, and each independently selected from the group consisting of H, D, halogen, C1-6 alkyl, and C1-6 haloalkyl;
• alternatively, R8 and R9 together with the atom to which they are attached form a 3- to 6-membered cycloalkyl ring, wherein the 3- to 6-membered cycloalkyl is optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxyl, C1-6 alkyl, and C1-6 haloalkyl;
• n is selected from the group consisting of 0, 1, 2, 3, and 4;
• m is selected from the group consisting of 0, 1, 2, 3, 4, and 5.