Substituted phenol derivative and use thereof

A compound of formula IA, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof, or a deuterated derivative thereof:

• wherein, R is selected from hydrogen, CORa, COCH(NH2)Ra1, COORh1, (CH2COO)vRh1, PO(ORh1)(ORh2) or CH2OPO(ORh1)(ORh2);
• Ra and Ra1 are each independently selected from hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl or heteroaryl;
• Rh1, Rh2 are each independently selected from hydrogen, C1-4 alkyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl or heteroaryl;
• v is an integer from 0-2;
• The bond connecting X can be a double bond or a single bond;
• when the bond connecting X is a double bond, X is selected from C;
• when the bond connecting X is a single bond, X is selected from CR3 and N;
• The bond connecting Y can be a double bond or a single bond;
• when the bond connecting Y is a double bond, Y is selected from C;
• when the bond connecting Y is a single bond, Y is selected from CR3 and N;
• Z is selected from none, CR5′, N, O;
• R1, R2, R11 and R12 are each independently selected from hydrogen, halogen, C1-4 alkyl, C1-4 alkenyl or 3-6 membered cycloalkyl;
• s is selected from an integer from 0 to 8, and each R6 is independently selected from hydrogen, C1-4 alkyl, halogenated C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, halogen, C1-4 alkoxy, CN, NO2, ORf, SRf, NRd1Rd2, CORi, (CRa1Ra2)mCORb;
• or, s is selected from an integer from 2 to 8, wherein two R6 are bounded form a ring, and the remaining R6 is each independently selected from hydrogen, C1-4 alkyl, halogenated C1-4 alkyl, halogen, C1-4 alkoxy, CN, NO2, ORf, SRf, NRd1Rd2, CORi, (CRa1Ra2)mCORb;
• R5 and R5′ are each independently selected from none, hydrogen, C1-8 alkyl, (CRa1Ra2)mCORb;
• R3 is hydrogen, (CRa1Ra2)mCOORb1, or groups including C1-4 alkyl, C2-4 alkonyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl or heteroaryl unsubstituted or optionally substituted by one or more Rx;
• wherein Rx is each independently selected from cyano, nitro, hydroxyl, carboxyl, halogen, C1-4 alkyl, C1-4 alkoxy, (CRa1Ra2)mNRd1Rd2, 3-8 membered cycloalkyl or its halogenated derivatives, 3-8 membered heterocyclyl or its halogenated derivatives, aryl or its halogenated or deuterated derivatives, heteroaryl or its halogenated or deuterated derivatives;
• R4 is hydrogen,
• (CRa1Ra2)mCOORb1, (CRa1Ra2)mOCORb, (CRa1Ra2)nCORc, CONRd1Rd2, (CRa1Ra2)nORf;
• when Z is none, X is N, Y is N, R4 is
• R7 is hydrogen or groups consisting of C1-4 alkyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl or heteroaryl unsubstituted or optionally substituted by one or more Ry;
• wherein Ry is each independently selected from cyano, nitro, hydroxyl, carboxyl, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, O(CRa1Ra2)mNRd1Rd2, (CRa1Ra2)mNRd1Rd2, 3-8 membered cycloalkyl or its halogenated derivatives, 3-8 membered heterocyclyl or its halogenated derivatives, aryl or its halogenated or deuterated derivatives, heteroaryl or its halogenated or deuterated derivatives;
• R8 is hydrogen, C1-4 alkyl, (CRa1Ra2)mCOORb1, (CRa1Ra2)mOCORb, (CRa1Ra2)nCORc, CONRd1Rd2, (CRa1Ra2)nORf, (CRa1Ra2)mSO2ORb1, (CRa1Ra2)mSOORb1;
• wherein, Ra1, Ra2 are each independently selected from hydrogen, halogen, C1-4 alkyl, halogenated C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl, heteroaryl, CN, ORf, SRf, or NRd1Rd2;
• or, Ra1 and Ra2, together with the carbon atom to which they are attached, form a 3-6 membered cyclic structure containing 0 or 1 heteroatom selected from N, O, or S;
• wherein, Rb1 is hydrogen, C1-4 alkyl, C1-4 alkoxy, halogenated C1-4 alkyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl, or heteroaryl;
• Rb is hydrogen, C1-4 alkyl, C1-4 alkoxy, halogenated C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl, or heteroaryl;
• Rc is hydrogen, C1-4 alkyl, C1-4 alkoxy, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, aryl, or heteroaryl;
• Rd1 and Rd2 are each independently selected from hydrogen, C1-4 alkyl, C1-4 alkoxy, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl;
• or, Rd1 and Rd2 taken together with the nitrogen atom to which they are attached form a 3-6 membered ring containinng 1 or 2 heteroatom selected from N, O, or S;
• wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl in Ra1, Ra2, Rd1, Rd2, Rb, Rb1, Rc, R5 and R5′ are unsubstituted or optionally substituted by one or more groups selected from halogen, C1-4 alkyl, C1-4 alkoxy, halogenated C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, 3-6 membered heterocyclyl, CN, NO2, ORf, SRf, NRd1Rd2, CORi, COORf OCORi, CONRd1Rd2, NRd1CORi, NRd1SO2Ri, or SO2Ri;
• Rf is selected from hydrogen, C1-4 alkyl, or halogenated C1-4 alkyl;
• Ri is selected from hydrogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3-6 membered cycloalkyl, or 3-6 membered heterocyclyl;
• m is 0, 1, 2;
• n is 0, 1, 2;
• r is 0, 1, 2, 3;
• p is 0, 1, 2, 3.