Amino lipid compound, and preparation method therefor and use thereof

An amino lipid compound having a structure of formula (V-6):

• or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof,
• wherein:
• L1 is C1-C6 hydrocarbylene, C3-C8 carbocyclic ring, heterocyclic ring, C1-C6 heterohydrocarbylene, or a bond;
• L7, L8, L11, and L12 are each independently C1-C18 hydrocarbylene, C1-C18 heterohydrocarbylene, or a bond;
• A7, and A8 are each independently —N(R4)—, —C(═O)O—, —OC(═O)—, —OC(═O)O—, —O—, —C(═O)—, —S—, —C(═O)S—, —SC(═O)—, —C(═O)N(R4)—, —N(R4)C(═O)—, —OC(═O)S—, —SC(═O)O—, —SC(═O)S—, —OC(═O)N(R4)—, —N(R4)C(═O)O—, —N(R4)C(═O)N(R4)—, —SC(═O)N(R4)—, —N(R4)C(═O)S—, —N(C(═O)L13OR4)—, —N(C(═O)L13SR4)—, —N(C(═O)R4), —N(L13OR4)—, —N(L13SR4)—, —OS(═O)O—, —OS(═O)2O—, —OP(═O)O—, —OP(═O)(OH)O—, —OP(═O)(H)O—, —OS(═O)2NH—, —NHS(═O)2O—, —OC(═O)C(═O)O—, —N(R4)C(═O)C(═O)O—, —OC(═O)C(═O)N(R4)—, —N(R4)C(═O)C(═O)N(R4)—,
• or a bond;
• each L13 is independently C1-C8 hydrocarbylene, or C1-C8 heterohydrocarbylene, or a bond;
• R1 and R2 are each independently —C(R6)(C(═O)OL14A12R7)2, —C(R6)(OC(═O)L14A12R7)2, —C(R6)(C(═O)OL14A12R7)R7, or —C(R6)(OC(═O)L14A12R7)R7;
• each A12 is independently —C(═O)O—, —OC(═O)—, —OC(═O)O—, —O—, —C(═O)—, —S—, —C(═O)S—, —SC(═O)—, —C(═O)N(R4)—, —N(R4)C(═O)—, —OC(═O)N(R4)—, —N(R4)C(═O)O—, —N(R4)C(═O)N(R4)—, —OC(═O)S—, —SC(═O)O—, —SC(═O)S—, —SC(═O)N(R4)—, —N(R4)C(═O)S—, —N(C(═O)L13OR4)—, —N(C(═O)L13SR4)—, —N(C(═O)R4), —N(L13OR4)—, —N(L13SR4)—, —N(R4)—, —OS(═O)O—, —OS(═O)2O—, —OP(═O)O—, —OP(═O)(OH)O—, —OP(═O)(H)O—, —OS(═O)2NH—, —NHS(═O)2O—, a benzene ring, or a bond;
• each R4 is independently H, C1-C6 hydrocarbyl, or C1-C6 heterohydrocarbyl;
• each R6 is independently H, C1-C6 hydrocarbyl, or C1-C6 heterohydrocarbyl;
• each L14 is independently C1-C18 hydrocarbylene, C1-C18 heterohydrocarbylene, or a bond;
• each R7 is independently C1-C24 hydrocarbyl or C1-C24 heterohydrocarbyl;
• and
• L15 is C1-C12 hydrocarbylene, C1-C12 heterohydrocarbylene, or a bond.