Crystal forms of amino lipids
AssigneeModernaTX, Inc.
InventorsOrn ALMARSSON, Eugene Cheung
Life of this patent
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Abstract
Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate (“Compound 1”), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (“Compound 2”), (3) heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate (“Compound 3”), and (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (“MC3”), and related compositions and methods.
Claims15
1-38. (canceled)
A salt or cocrystal of heptadecan-9-yl 8-((2-hydroxyethyl) (8-(nonyloxy)-8-oxooctyl)amino) octanoate (“Compound 3”) and trimesic acid, wherein the salt or cocrystal exhibits an X-ray powder diffraction pattern obtained using Cu Kα radiation, comprising two, three, four, or more characteristic peaks expressed in degrees 2-theta (+/−0.2) selected from the group consisting of 6.2, 10.8, 12.4, 16.5, 18.7, 22.5, and 26.7.
(canceled)
46-47. (canceled)
50-94. (canceled)
Dependencies are inferred from the claim text.