Chromatographic composition and methods of producing the chromatographic composition
AssigneeAdvanced Materials Technology, Inc.
InventorsBarry Edward Boyes, Marc B. Goldfinger
Life of this patent
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Abstract
A chromatographic composition includes a solid phase substrate and a first ligand covalently bonded to the solid phase substrate. The first ligand covalently bonded to the solid phase substrate is represented by Formula (I): Formula (I). In Formula (I), R1 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group; R2 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group; n is 2 to 8; m is 0 to 4; X is oxygen or nitrogen; and Y is a substituted or unsubstituted cyclic ring(s) structure including at least one nitrogen atom.
Claims38
A chromatographic composition comprising:
- a solid phase substrate;
- and
- a first ligand covalently bonded to the solid phase substrate and represented by Formula I:
- wherein
- R1 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group,
- R2 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group;
- n is 2 to 8;
- m is 0 to 4
- X is O or N, and
- Y is a substituted or unsubstituted cyclic ring(s) structure including at least one nitrogen atom.
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A method of producing a chromatographic composition, the method comprising:
- providing a solid phase substrate,
- providing a first ligand portion represented by Formula IV
- wherein R1 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group,
- R2 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group,
- R7 is a leaving group;
- and
- n is 2 to 8;
- reacting the solid phase substrate and the first ligand portion to covalently couple the solid phase substrate and the first ligand portion and form a first intermediate;
- providing an amide-forming reaction compound represented by Formula V:
- wherein R7 is a leaving group and Y is the substituted or unsubstituted cyclic ring(s) structure including at least one nitrogen atom, and
- reacting the amide-forming reaction compound and the first intermediate to produce a first ligand covalently coupled to the solid phase substrate and thereby produce the chromatographic composition.
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A method of producing a chromatographic composition, the method comprising:
- providing a first ligand portion represented by Formula IV:
- wherein R1 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group,
- R2 is independently selected from H or a straight or branched, substituted or unsubstituted, C1 to C18 alkyl group,
- R7 is a leaving group;
- and
- n is 2 to 8;
- providing an amide-forming reaction compound represented by Formula V:
- wherein R7 is a leaving group and Y is the substituted or unsubstituted cyclic ring(s) structure including at least one nitrogen atom;
- reacting the first ligand portion and the amide-forming reaction compound to produce an off-particle reaction product;
- providing a solid phase substrate;
- and
- reacting the solid phase substrate and the off-particle reaction product to covalently couple the solid phase substrate and the off-particle reaction product and thereby produce the chromatographic composition.
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Dependencies are inferred from the claim text.