Therapeutic ultrasonication system for opening blood-brain barrier and ultrasonic wave control method of therapeutic ultrasonication system for opening blood-brain barrier

An ultrasonic wave control method of a therapeutic ultrasonication system for blood-brain barrier opening, which is driven by at least one processor, the method comprising the steps of:

• (a) setting, by the at least one processor, an output condition for outputting ultrasound energy to an acoustic cavitation generation material injected into an object;
• (b) outputting, by the at least one processor, ultrasound energy corresponding to the output condition to the object;
• (c) receiving, by the at least one processor, an acoustic signal due to an acoustic cavitation phenomenon of the acoustic cavitation generation material;
• (d) analyzing, by the at least one processor, the acoustic signal to determine whether a preset control condition is satisfied;
• and
• (e) depending on whether the preset control condition is satisfied, stopping, by the at least one processor, the output of the ultrasound energy or adjusting at least one of output conditions to output the ultrasound energy, wherein the output conditions include a duty cycle, the number of stimulus pulses per preset time, a pulse repetition frequency per preset time, and an applied voltage.