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AssigneesVC Cell Therapy (VCCT Inc.), Kobe City Hospital Organization
InventorsMichiko MANDAI, Tomohiro MASUDA, Mitsuhiro NISHIDA
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The present invention relates to a method for producing a sheet for transplantation from a retinal organoid derived from pluripotent stem cells, and the like. Specifically, the present invention relates to a method for producing a retinal sheet for transplantation from a retinal organoid derived from pluripotent stem cells, the method including a step of performing optical coherence tomography (OCT) on the retinal organoid derived from pluripotent stem cells to identify, as a region suitable for transplantation, a region with a thickness of 70 μm or more and free of foreign structures characterized by differences in brightness, and a step of excising a fragment from the region suitable for transplantation to obtain the retinal sheet for transplantation.
A method for producing a retinal sheet for transplantation from a retinal organoid derived from pluripotent stem cells, the method comprising:
A medicament for the treatment of retinal degenerative diseases, comprising a plurality of cell sheets for retinal transplantation excised from a single planar retinal organoid derived from pluripotent stem cells, and a transplantation medium, wherein the plurality of cell sheets for retinal transplantation each have a size with a length of 1.0 to 10.0 mm in the long axis direction and 0.5 to 2.0 mm in the short axis direction, and have been confirmed by optical coherence tomography (OCT) to have a thickness of 70 μm or more and to be free of foreign structures.
Dependencies are inferred from the claim text.