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AssigneesDaikin America, Inc., Daikin Industries, Ltd.
InventorsYuki KUWAJIMA, Lensey SMITH, Keisuke HAGI, Takeshi INABA, Hiroaki WADA
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Bioprocess bags are provided which retain good mechanical characteristics after radiation sterilization. The bags are constructed from a copolymer of tetrafluoroethylene. The tetrafluoroethylene is polymerized with at least one monomer selected from the group consisting of: ethylene; chlorotrifluoroethylene; vinyl fluoride; hexafluoropropylene; hexafluoroisobutene; monomers represented by CH2═CX1(CF2)nX2 (wherein X1 is H or F, X2 is H, F, or Cl, and n is an integer of 1 to 20); perfluoro(alkyl vinyl ethers) represented by CF2═CF—ORf1 (wherein Rf1 is a C1-C20 perfluoroalkyl group or a C1-C17 perfluoroalkoxy alkyl group); and alkyl perfluorovinyl ether derivatives represented by CF2═CF—OCH2—Rf2 (wherein Rf2 is a C1-C5 perfluoroalkyl group). A particular version is polymerized with ethylene and CH2═CX1(CF2)nX2 (wherein X1 is H or F, X2 is H, F, or Cl, and n is an integer of 1 to 20). Various versions of the bag have high resistance to repeated bending, folding, and creasing; low water vapor transmissibility; high puncture resistance; high biocompatibility; and low reactivity. This makes them suitable for storing biomaterials and medical materials.
A bioprocess bag constructed from a copolymer formed from the following monomers:
A bioprocess bag constructed from a copolymer formed from the following monomers:
A bioprocess bag constructed from a copolymer formed from the following monomers:
A bioprocess bag constructed from a copolymer formed from the following monomers:
A method of making a bioprocess bag, the method comprising:
A method of making a bioprocess bag, the method comprising:
Any one of the bioprocess bags or methods above, wherein X1 is H and X2 is F.
Any one of the bioprocess bags or methods above, wherein the third monomer is selected from:
Any one of the bioprocess bags or methods above, wherein the third monomer has the formula CH2═CF(CF2)3H, and is 1.7-4.0% mol/mol of the collective mole of the monomers.
Any one of the bioprocess bags or methods above, wherein the third monomer is selected from CH2═CH(CF2)5CF3, CH2═CH(CF2)3CF3, or both;
Any one of the bioprocess bags or methods above, wherein the bioprocess bag has a puncture resistance of at least 2800 J at −70° C. as measured by ASTM D3763-18 (2018) after exposure to 50 kGy of γ radiation;
Any one of the bioprocess bags or methods above, wherein the bioprocess bag is configured to contain a biomaterial or medical material.
Any one of the bioprocess bags or methods above, wherein the bioprocess bag is configured to be sterilized by ionizing radiation.
Any one of the bioprocess bags or methods above, wherein the bioprocess bag is configured to store a material at cryogenic temperatures.
A method of sterilizing a bioprocess bag, comprising:
Dependencies are inferred from the claim text.