Extracellular vesicles targeting dendritic cells and uses thereof
AssigneeLonza Sales AG
InventorsNikki ROSS, Dalia BURZYN, Sriram SATHYANARAYANAN, Raymond J. MONIZ, Ke XU, Shelly Ann MARTIN, Kevin DOOLEY
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Abstract
The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising a targeting moiety, wherein the targeting moiety can specifically bind to markers expressed on distinct immune cells (e.g., dendritic cells). Also provided herein are methods for using the exosomes to treat and/or prevent a range of medical disorders.
Claims30
An extracellular vesicle (EV) comprising an exogenous targeting moiety that specifically binds to a marker for a dendritic cell.
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Dependencies are inferred from the claim text.