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US 2026/0216366 A1Published application
Conjugate and uses thereof
AssigneeFull-Life Technologies UK Limited
InventorsXiaozhu WANG, Chung Lim WONG
Life of this patent
Estimating the term…
Abstract
A conjugate comprises: (a) a single-domain antibody (sdAb) that specifically binds to a tumor antigen, (b) a drug, and (c) a functional linker which links the drug to the sdAb. The use of the conjugate is treating cancer. The method for preparing the conjugate comprises conjugating the functional linker and the drug to the sdAb.
Claims35
A conjugate comprising:
- (a) a single-domain antibody (sdAb) that specifically binds to a tumor antigen;
- (b) a drug;
- and
- (c) a functional linker comprising a functional moiety, wherein the functional linker links the drug to the sdAb, wherein the functional linker increases tumor uptake, accumulation, and/or retention of the drug when the conjugate is administered to a subject compared to a conjugate without the functional moiety, and wherein the functional moiety comprises a blood protein binding group.
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A conjugate comprising:
- (a) an antibody mimetic that specifically binds to a tumor antigen, wherein the antibody mimetic is selected from the group consisting of an Affibody, a DARPin, an Anticalin, an Avimer, a Versabody, and a Duocali;
- (b) a drug;
- and
- (c) a functional linker comprising a functional moiety, wherein the functional linker links the drug to the antibody mimetic, and wherein when the conjugate is administered to a subject, compared to a conjugate without the functional moiety, the functional linker is able to:
- (i) increase tumor uptake, accumulation, and/or retention of the drug, (ii) decrease kidney uptake, accumulation, and/or retention of the drug, (iii) increase tumor/kidney ratio of the drug, (iv) prolong blood circulation of the drug, and/or (v) extend half-life of the drug.
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Dependencies are inferred from the claim text.