Cyclic peptide-based lysosome targeting degraders

Abstract

Provided herein are bifunctional lysosomal targeting degraders that comprise a peptide ligand that binds to RGD-binding integrin as a shuttle molecule for lysosome degradation, and a protein binder that binds a membrane or extracellular protein of interest. The bifunctional degraders find use, e.g., for selectively targeted degradation of membrane and extracellular proteins via the endosomal/lysosomal pathway. Also provided herein are compositions comprising the bifunctional degraders, as well as methods of using the bifunctional degraders.

Dependencies are inferred from the claim text.