Lipid antibody oligonucleotide conjugates compositions and uses thereof
AssigneeAtrium Therapeutics, Inc.
InventorsVenkata Ramana DOPPALAPUDI, Michael Caramian COCHRAN, Subbarao NALLAGATLA, Tyler ALBIN, Isaac MARKS, Varun GOEL, Marc Andrew HARTMANN
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Abstract
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule linked to a lipophilic moiety. Also described herein include methods for treating a disease or disorder which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule linked to a lipophilic moiety.
Claims20
A polynucleotide conjugate comprising a binding moiety conjugated to a polynucleotide molecule, wherein the polynucleotide conjugate further comprises a lipophilic moiety.
Use of a polynucleotide conjugate in a method of delivering a polynucleotide molecule to a tissue of a subject comprising administering the polynucleotide conjugate, wherein the polynucleotide conjugate comprises a binding moiety conjugated to a polynucleotide molecule, wherein the polynucleotide conjugate further comprises a lipophilic moiety.
Use of a polynucleotide conjugate in a method of treating muscle atrophy or myotonic dystrophy in a subject in need thereof comprising administering the polynucleotide conjugate, wherein the polynucleotide conjugate comprises a binding moiety conjugated to a polynucleotide molecule, wherein the polynucleotide conjugate further comprises a lipophilic moiety.
Dependencies are inferred from the claim text.