Antibody-drug conjugate from n-oxycycloalkyl substituted camptothecin derivative

An antibody-drug conjugate represented by Formula (I),

• in the Formula,
• m, n1 are each independently selected from 1 or 2;
• Ra is selected from hydrogen and -L1-NH-Lp-Z-Ab, Rb is selected from hydrogen, -L2-NH-Lp-Z-Ab and -L3-NH—Z-Ab, provided that Ra, Rb are not both hydrogen;
• wherein,
• L1 is selected from —C(═O)-L11-L12-L13-;
• L11, L12, L13 are each independently selected from —O—, C1-C3 alkylene and phenyl;
• L2 is selected from —C(═O)—NH-L21-CHR1—;
• L21 is selected from —C(═O)— and —NH—C(═O)—;
• R1 is selected from hydrogen, deuterium, C1-C6 alkyl and phenyl-substituted C1-C6 alkyl;
• L3 is selected from —C(═O)—NR2—NR3-L31-L32-;
• R2, R3 are each independently selected from hydrogen, deuterium and C1-C6 alkyl;
• L31 is selected from —C(═O), —(C1-C3 alkylene)-C(═O), -5-8 membered aryl-C(═O)—, -5-8 membered azaheteroaryl-C(═O)— and —O—(C1-C3 alkylene)-C(═O)—;
• L32 is selected from —NH—(C1-C3 alkylene), —N(CH3)2—(C1-C3 alkylene) and —NH—(C1-C3 alkylene)—NH—;
• LP is a peptide residue consisting of 2 to 7 amino acids;
• Z is selected from -Lz-Lj-, wherein, Lz is selected from —C(═O)—C1-C8 alkylene, —C(═O)—CH2O—(CH2CH2O)2-5—CH2CH2NH—, —C(═O)—(CH2CH2O)2-6—CH2CH2— and —C(═O)—(CH2CH2O)2-6—CH2CH2NH—, Lj is a linker that can conjugate to an antibody;
• Ab is an antibody.