Irak degradation agent and use thereof

A compound of Formula I:

• or a stereoisomer or pharmaceutically acceptable salt thereof, wherein:
• V is —C(O)NH— or —NHC(O)—;
• T is —NH— or a bond;
• represents a single bond or a double bond;
• Y2 and Y3 are each independently C or N;
• Y1 and Y4 are each independently selected from CRY, CRYRY, N, NRY, O, S, C(O), S(O), and S(O)2;
• Y5 is C or N;
• Y6 and Y7 are each independently CR4 or N;
• each RY is independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, and halogen-substituted C2-6 alkynyl;
• Q is CRQ or N;
• RQ is selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C1-6 alkoxy, halogen-substituted C1-6 alkyl, and halogen-substituted C1-6 alkoxy;
• ring A is 5- to 10-membered heteroaryl, wherein the heteroaryl is optionally substituted with 1, 2, or 3 RAl:
• each RA1 is independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, —C0-2 alkylene-ORA2, —C0-2 alkylene-NRA2RA3, —C0-2 alkylene-3- to 10-membered carbocyclyl, and —C0-2 alkylene-4- to 10-membered heterocyclyl;
• RA2 and RA3 are each independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl;
• R1 and R4 are each independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, —C0-2 alkylene-OR11, —C0-2 alkylene-NR11R12, —C0-2 alkylene-NR11C(O)R12, —C0-2 alkylene-C(O)R11, —C0-2 alkylene-C(O)NR11R12, —C0-2 alkylene-3- to 10-membered carbocyclyl, —C0-2 alkylene-4- to 10-membered heterocyclyl, —C0-2 alkylene-4- to 10-membered bridged carbocyclyl, —C0-2 alkylene-4- to 10-membered bridged heterocyclyl, —C0-2 alkylene-5- to 12-membered spiro carbocyclyl, —C0-2 alkylene-5- to 12-membered spiro heterocyclyl, —C0-2 alkylene-6- to 10-membered aryl, and —C0-2 alkylene-5- to 10-membered heteroaryl, wherein the carbocyclyl, heterocyclyl, bridged carbocyclyl, bridged heterocyclyl, spiro carbocyclyl, spiro heterocyclyl, aryl, or heteroaryl is optionally substituted with 1, 2, or 3 R13;
• R11 and R12 are each independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl;
• each R13 is independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, —C0-2 alkylene-OR11, —C0-2 alkylene-NR14R15, —C0-2 alkylene-NR14C(O)R15, —C0-2 alkylene-C(O)R14, and —C0-2 alkylene-C(O)NR14R15;
• R14 and R15 are each independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl;
• ring D is
• where the cc end is attached to L, and the dd end is attached to Q;
• X2 and X3 are each independently C or N;
• X1 and X4 are each independently selected from CRX, CRXRX, N, NRX, O, S, C(O), S(O), and S(O)2;
• X5 is C or N;
• X6 and X7 are each independently CR2 or N;
• X8 and X9 are each independently selected from C, CR2, and N;
• each RX is independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, and halogen-substituted C2-6 alkynyl;
• each R2 is independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-4 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, —C0-2 alkylene-OR21, —C0-2 alkylene-NR21R22, —C0-2 alkylene-3- to 10-membered carbocyclyl, and —C0-2 alkylene-4- to 10-membered heterocyclyl;
• R21 and R22 are each independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl;
• L is
• where ring B is attached to Y5, and ring C is attached to ring D;
• ring B is selected from 3- to 10-membered carbocyclyl, 4- to 10-membered heterocyclyl, 4- to 10-membered bridged carbocyclyl, 4- to 10-membered bridged heterocyclyl, 5- to 12-membered spiro carbocyclyl, 5- to 12-membered spiro heterocyclyl, 6- to 10-membered aryl, and 5- to 10-membered heteroaryl, wherein the carbocyclyl, heterocyclyl, bridged carbocyclyl, bridged heterocyclyl, spiro carbocyclyl, spiro heterocyclyl, aryl, or heteroaryl is optionally substituted with 1, 2, or 3 RB;
• ring C is selected from 3- to 10-membered carbocyclyl, 4- to 10-membered heterocyclyl, 4- to 10-membered bridged carbocyclyl, 4- to 10-membered bridged heterocyclyl, 5- to 12-membered spiro carbocyclyl, 5- to 12-membered spiro heterocyclyl, 6- to 10-membered aryl, and 5- to 10-membered heteroaryl, wherein the carbocyclyl, heterocyclyl, bridged carbocyclyl, bridged heterocyclyl, spiro carbocyclyl, spiro heterocyclyl, aromatic ring, or heteroaryl is optionally substituted with 1, 2, or 3 RC;
• RB and RC are each independently selected from hydrogen, deuterium, halogen, cyano, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, —C0-2 alkylene-ORB1, and —C0-2 alkylene-NRB1RB2;
• RB1 and RB2 are each independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl;
• L1 is selected from a bond, C1-6 alkylene, C2-6 alkenylene, and C2-6 alkynylene;
• wherein the carbon atom in the alkylene, alkenylene, or alkynylene is optionally substituted with 1, 2, or 3 heteroatoms, and the alkylene, alkenylene, or alkynylene is optionally substituted with 1, 2, or, 3 RLL;
• and
• each RL1 is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen-substituted C1-6 alkyl, halogen-substituted C2-6 alkenyl, halogen-substituted C2-6 alkynyl, deuterated C1-6 alkyl, deuterated C2-6 alkenyl, and deuterated C2-6 alkynyl.