Keto acid biopolymers and polyol keto esters and uses thereof

Abstract

Described herein are compositions comprising alpha-keto acid analogues of amino acids. The alpha-keto acids may be in a composition also comprising a biopolymer such as chitosan. The alpha-keto acid analogues of amino acids may be bonded to a chitosan backbone. The alpha-keto acids may be in a composition with polyol compounds to form polyol keto esters. Also described herein are consumable compositions such as medical foods containing either the chitosan alpha-keto acid compositions or polyol keto ester compositions that may be used as protein supplements for patients with kidney disease or at risk of developing kidney disease. The compositions may be used to treat or prevent a kidney disease by increasing blood amino acid levels and suppressing blood ammonia and urea levels.

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