Cochleates made with soy phosphatidylserine
AssigneesRutgers, The State University of New Jersey, Matinas Biopharma Nanotechnologies, Inc.
InventorsRaphael Mannino, Ruying Lu
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Abstract
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
Claims28
A cochleate comprising:
- a soy-based phospholipid that comprises about 40%-74% by weight soy phosphatidylserine,
- a multivalent cation, and
- a biological active.
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A method for producing soy-based phosphatidylserine/biological active cochleates which comprises the steps of:
- a. preparing liposomes in an aqueous medium wherein the liposomes have (i) a lipid bilayer comprising soy phosphatidylserine in an amount of about 40%-74% by weight of the lipid bilayer and (ii) a load of a biological active;
- b. adding a multivalent cation to the suspension of liposomes of (a) to form the soy phosphatidylserine/biological active cochleates;
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- c. collecting the soy-based phosphatidylserine/biological active cochleates.
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A method of treating a patient with a fungal infection which comprises administering to the patient an effective anti-fungal amount of a cochleate which comprises (i) a soy-based phospholipid that comprises about 40%-74% or 45%-55% by weight soy phosphatidylserine, (ii) a multivalent cation and (iii) an anti-fungal agent.
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Dependencies are inferred from the claim text.