Mixed nut allergen formulations and methods of making and using the same
AssigneeSociete des Produits Nestle S.A.
InventorsAbhi KATHURIA, Jonathan James GILROY
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Abstract
The present disclosure provides, in part, compositions comprising mixed allergen powders of one or more nut flours and one or more excipients, methods of producing the compositions, and methods of using the same for the prevention and treatment of nut allergies.
Claims67
A mixed allergen powder comprising a plurality of tree nut flours and further comprising an excipient, the excipient having a particle size up to about 150 microns,
- the plurality of tree nut flours preferably each having a particle size up to about 100 microns, more preferably up to about 50 microns.
A method of making a mixed allergen powder, the method comprising:
- mixing a plurality of tree nut flours with an excipient,
- the excipient having a particle size up to about 150 microns,
- the plurality of tree nut flours preferably each having a particle size up to about 100 microns, more preferably up to about 50 microns.
A method of making a mixed allergen powder, the method comprising:
- providing an excipient that has been spray-dried;
- and mixing a plurality of tree nut flours with the excipient.
A composition comprising:
- a mixed allergen powder comprising one or more nut allergen peptides, wherein the mixed allergen powder comprises a particle size of less than about 100 μm;
- and
- one or more excipients comprising a particle size up to about 150 μm.
A composition comprising:
- a mixed allergen powder comprising cashew flour, hazelnut flour, walnut flour, and peanut flour, wherein the mixed allergen powder has a particle size of less than about 100 μm;
- and
- one or more excipients comprising pregelatinized starch, microcrystalline cellulose, guar gum, agglomerated spherical isomalt, mannitol, sorbitol, sucrose, lactose, maltodextrin, fumed silica, micronized talc, and magnesium stearate, wherein the one or more excipients has a particle size up to about 150 μm.
A composition consisting of:
- a mixed allergen powder consisting of cashew flour, hazelnut flour, walnut flour, and peanut flour, wherein the mixed allergen powder has a particle size of less than about 100 μm;
- and
- one or more excipients selected from pregelatinized starch, microcrystalline cellulose, guar gum, agglomerated spherical isomalt, mannitol, sorbitol, sucrose, lactose, maltodextrin, fumed silica, micronized talc, and magnesium stearate, wherein the one or more excipients has a particle size up to about 150 μm.
Dependencies are inferred from the claim text.