Immunogenic compositions and methods of inducing an immune response against varicella zoster virus
AssigneePfizer Inc.
InventorsPirada Suphaphiphat Allen, Annaliesa Sybil Anderson, Kathrin Ute Jansen, Jody Lawrence, Alicia Solorzano Quijano, Christopher Frederick Webber
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Abstract
The present disclosure provides for methods of inducing an immune response against varicella zoster virus (VZV) in a human subject. The methods provided herein comprise administering immunogenic compositions (e.g., vaccines) comprising RNA molecules formulated in a lipid nanoparticle to a human subject. The present disclosure further relates to the use of immunogenic compositions for preventing or treating of Herpes zoster in a human subject.
Claims32
A method of inducing an immune response against varicella zoster virus (VZV) in a human subject, the method comprising administering to the subject an effective amount of an immunogenic composition comprising an RNA molecule encoding a VZV glycoprotein E (gE) polypeptide, wherein VZV gE binding antibodies are induced in the subject.
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A method of preventing, treating, ameliorating and/or reducing the risk of an infection, disease or condition associated with VZV in a human subject, the method comprising administering to the subject an effective amount of an immunogenic composition comprising an RNA molecule encoding a VZV glycoprotein E (gE) polypeptide, wherein VZV gE binding antibodies are induced in the subject.
Dependencies are inferred from the claim text.