Il-36 cytokine expressing oncolytic viruses for treating cancer
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsZong Sheng GUO, Binfeng LU, David L. BARTLETT
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Abstract
The present disclosure provides interleukin-36 (IL-36) cytokine (e.g., IL-36γ) expressing oncolytic viruses, and compositions comprising thereof. The present disclosure further provides methods of using said oncolytic viruses and compositions for treating cancer, and for improving a subject's responsiveness to an immunomodulatory agent.
Claims19
A method of treating cancer in a subject in need thereof, comprising administering to the subject an oncolytic vaccinia virus comprising a recombinant nucleic acid molecule encoding interleukin-36γ (IL-36γ).
A method of treating cancer in a subject in need thereof, comprising administering to the subject a combinatorial therapy comprising (i) an oncolytic vaccinia virus comprising a recombinant nucleic acid molecule encoding IL-36γ and (ii) an immunomodulatory agent.
Dependencies are inferred from the claim text.