Composition for preventing and treating ischemic cerebrovascular disease comprising gintonin

Abstract

The present invention relates to a composition for the prevention and treatment of ischemic cerebrovascular diseases, including cerebral infarction, comprising gintonin as an active ingredient. Gintonin of the present invention reduces cerebral infarction volume and can increase survival rate after the onset of cerebral infarction. In addition, the neuroprotective effect and damage prevention effect of gintonin pretreatment on human brain microvascular endothelial cells (HBMECs), which are human brain-derived vascular endothelial cells, and the neuroprotective effect and therapeutic effect of gintonin post-treatment were confirmed. As a result of mechanism verification, it was found that gintonin was effective in recovering the level of reduced nitric oxide (NO), which is known to be involved in the onset and pathophysiology of cerebral infarction. Therefore, the present invention can be used to improve the prevention and treatment of ischemic cerebrovascular diseases, including cerebral infarction, and thus, medical costs can be reduced.

Dependencies are inferred from the claim text.