Compositions and methods for modulating complement activity

Abstract

Embodiments of the disclosure provide sustained release formulations that include active ingredients and release modulating matrices. Also provided are related methods of preparation and methods of addressing therapeutic indications with sustained release formulations described herein. Included are sustained release formulations with complement inhibitors (e.g., C5 inhibitory cyclic polypeptides, zilucoplan, and/or active metabolites or variants thereof) for treating complement-related indications.

Dependencies are inferred from the claim text.