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AssigneeAkamis Bio Limited
InventorsJohn Beadle, Kerry Fisher, Christine Wilkinson Blanc
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The present disclosure provides a method of treating a human patient comprising the steps of: systemically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1×1010 to 1×1014 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2×1010 particles per minute to 2×1012 particles per minute. The disclosure further extends to formulations of the said oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents.
1-27. (canceled)
A method of treating cancer in a human subject in need thereof, the method comprising at least a first treatment cycle, wherein a single treatment cycle comprises administering to the subject multiple doses of a formulation of a replication competent subgroup B oncolytic adenovirus, the multiple doses comprising at least a first dose and a second dose, wherein each of the multiple doses is in the range of 1×1010 to 1×1014 viral particles, and wherein the period between each of the multiple doses is in the range of 6 hours to 72 hours.
Dependencies are inferred from the claim text.