Methods of Treating Skin Inflammation and Related Compositions

Abstract

Provided are methods of treating skin inflammation in a subject in need thereof. The methods comprise administering to the subject a composition comprising Akkermansia muciniphila and/or an Akkermansia muciniphila supernatant or fraction thereof comprising one or more agents that reduce skin inflammation (e.g., gluconic acid, gluconolactone, 5-aminolevulinic acid, azelaic acid, glycero-phosphatidylcholine, glycero-phosphatidylinositol, or any combination thereof), in an amount effective to treat the skin inflammation. According to some embodiments, the composition is administered orally or topically. In certain embodiments, prior to the administering, the subject has been identified as having an inflammatory skin disorder, e.g., actinic keratoses, psoriasis, acne, rosacea, seborrheic dermatitis, eczema, or the like. Also provided are topical formulations comprising an Akkermansia muciniphila supernatant or fraction thereof comprising one or more agents that reduce skin inflammation. According to some embodiments, the topical formulation is a lotion, cream, ointment, gel, paste, aerosol spray, aerosol foam, or transdermal patch.

Dependencies are inferred from the claim text.