Cell-microsphere co-assembly, and preparation method therefor and use thereof

A cell-microsphere co-assembly, characterized in that it is formed by the co-assembly of hydrogel microspheres and cells;

• the ratio of the hydrogel microspheres to cells is 0.0001-10 μL:101-7 cells;
• the hydrogel microspheres are microspheres prepared by mixing any one or more of synthetic materials, natural materials, or derivative materials with photoinitiators;
• the synthetic materials comprise polyethylene glycol, polyvinyl alcohol, povidone, polylactic acid, polycaprolactone, polyurethane, or polyglycerol sebacate;
• the natural materials comprise gelatin, sodium alginate, sodium hyaluronate, chitosan, fibrin, collagen, or decellularized extracellular matrix (dECM);
• the derivative materials comprise poly(ethylene glycol) diacrylate (PEGDA), methacryloylated poly(vinyl alcohol), methacryloylated polycaprolactone, methacryloylated polylactic acid, polyurethane methacrylate, gelatin methacryloyl (GelMA), sodium methacryloylated hyaluronate, sodium methacryloylated alginate, chitosan methacryloyl (CSMA), methacryloylated fibrin, methacryloylated collagen, or methacryloylated decellularized extracellular matrix.