Composition For Treatment Or Prevention Of Hair Loss Comprising Stem Cell-Derived Exosomes And Preparation Method Therefor
AssigneeBrexogen Inc.
InventorsSue KIM, Hyun Geun OH
Life of this patent
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Abstract
The present invention relates to a composition for the treatment of hair loss, comprising stem cell-derived exosomes, and a preparation method therefor. The exosomes according to the present invention have an excellent growth and recovery promoting effect on human hair papilla cells, and thus can be used for various cosmetics and pharmaceutical compositions for the treatment of hair loss.
Claims13
-5. (canceled)
A cosmetic composition for improving scalp condition, strengthening hair roots, supporting hair follicle health, or enhancing the appearance of hair, comprising exosomes isolated from induced pluripotent stem cell-derived mesenchymal stem cells (iPSCs) as an active ingredient.
A method for preparing a pharmaceutical composition comprising exosomes for use in treating hair loss, the method comprising:
- a first culturing step of culturing induced pluripotent stem cells in a medium;
- a selective culturing step of isolating SSEA-4(—) cells that do not express SSEA-4 protein from the cultured induced pluripotent stem cells and culturing same to differentiate into BxC stem cells;
- a second culturing step of culturing the BxC stem cells to differentiate into mesenchymal stem cells;
- a pretreatment step of pretreating the mesenchymal stem cells with hyaluronic acid;
- a production step of culturing the pretreated mesenchymal stem cells to produce exosomes;
- and
- a collection step of obtaining the culture supernatant from the mesenchymal stem cells or the culture thereof.
A method for treating, preventing, alleviating, or suppressing hair loss in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising exosomes isolated from mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs).
Dependencies are inferred from the claim text.