Treatment Methods for ALS Patients
AssigneesNeuvivo, Inc., The Regents of the University of California
InventorsArasteh Azhir, Michael S. McGrath, Bruce D. Forrest, Leah Price
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Abstract
Provided herein are methods and compositions for the treatment of ALS using chlorite or a pharmaceutical composition comprising sodium chlorite, for a target ALS patient population. Also provided herein are methods for identifying a target ALS patient population likely to be responsive to treatment with chlorite or a pharmaceutical composition comprising sodium chlorite, the methods including identifying ALS patients with elevated plasma C-reactive protein (CRP) levels and/or patients age 40-65, sporadic ALS pathology, or combinations thereof.
Claims21
1-117. (canceled)
A method of treating amyotrophic lateral sclerosis (ALS) in a subject, the method comprising administering to the subject chlorite, wherein the subject is age 40-65, has an elevated level of CRP, and has experienced a symptom of ALS for at least 12 months.
A kit comprising:
- a) an aqueous pharmaceutical formulation of sodium chlorite;
- and
- b) written instructions comprising a description of contacting the aqueous pharmaceutical formulation of sodium chlorite with a saline solution to provide a diluted sodium chlorite formulation and administering the diluted sodium chlorite formulation to a subject who has experienced ALS for at least 12 months prior to the administering.
Dependencies are inferred from the claim text.