Composition comprising estetrol and drospirenone for use in relieving and treating pain
AssigneeEatetra Srl
InventorsMasashi HIRAYAMA, Masayoshi NOGAMI
Life of this patent
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Abstract
The present invention relates to a pharmaceutical composition comprising estetrol and drospirenone for use in relieving pain associated with endometriosis in a subject. The pharmaceutical composition described herein is particularly effective in relieving pain associated with endometriosis in subjects that report a high degree, frequency, and/or intensity of pain, such as measured by the Visual Analogue Scale (VAS) score, and/or have a further complication such as adenomyosis or uterine fibroids. Also described herein are uses related to the above and corresponding methods of treatment.
Claims19
1-18. (canceled)
A method of relieving pain associated with endometriosis, comprising administering to a subject in need thereof a pharmaceutical composition comprising from about 13.5 mg to about 16.5 mg estetrol or a hydrate thereof and from about 2.5 mg to about 3.5 mg drospirenone.
A method of treating a subject suffering from pelvic pain, comprising administering to the subject a pharmaceutical composition comprising from about 13.5 mg to about 16.5 mg estetrol or a hydrate thereof and from about 2.5 mg to about 3.5 mg drospirenone.
A method of relieving pain associated with endometriosis in a subject in need thereof, comprising:
- identifying a subject who has pelvic pain prior to treatment with a VAS score of greater than about 40 mm, about 50 mm, about 60 mm, or about 70 mm, and
- administering to the identified subject a pharmaceutical composition comprising from about 13.5 mg to about 16.5 mg estetrol or estetrol monohydrate and about 2.5 mg to about 3.5 mg drospirenone.
Dependencies are inferred from the claim text.