Dry Powder Treprostinil for the Treatment of Pulmonary Hypertension
AssigneeLiquidia Technologies, Inc.
InventorsRobert Frank Roscigno, Brian T. Farrer, Jacob J. Sprague, Benjamin Maynor
Life of this patent
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Abstract
A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.
Claims16
-27. (canceled)
A kit for administering treprostinil or a pharmaceutically acceptable salt thereof to a patient in need thereof, the kit comprising:
- a plurality of dosage units containing inhalable drug particles comprising treprostinil or a pharmaceutically acceptable salt thereof, each dosage unit of the plurality dosage units including a predetermined amount of the treprostinil or the pharmaceutically acceptable salt thereof selected from:
- about 15 micrograms to about 20 micrograms;
- about 20 micrograms to about 25 micrograms;
- about 25 micrograms to about 30 micrograms;
- about 30 micrograms to about 35 micrograms;
- about 35 micrograms to about 45 micrograms;
- about 45 micrograms to about 50 micrograms;
- about 50 micrograms to about 55 micrograms;
- about 55 micrograms to about 60 micrograms;
- about 60 micrograms to about 65 micrograms;
- about 65 micrograms to about 75 micrograms;
- about 75 micrograms to about 80 micrograms;
- about 80 micrograms to about 100 micrograms;
- or
- about 100 micrograms to about 110 micrograms;
- and
- a dry powder inhaler comprising:
- a body configured to receive a dosage unit selected from the plurality of dosage units;
- and
- a mouthpiece,
- wherein the selected dosage unit is opened when the selected dosage unit is received by the body to allow delivery of inhalable drug particles from the selected dosage unit to the patient through the mouthpiece via inhalation.
Dependencies are inferred from the claim text.