Pharmaceutical compositions comprising meloxicam
AssigneeAxsome Therapeutics, Inc.
InventorHerriot Tabuteau
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Abstract
Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of meloxicam and/or rizatriptan for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura.
Claims18
A method of treating migraine, comprising:
- administering a tablet containing 20 mg of meloxicam, or a molar equivalent amount of a salt of meloxicam, and 10 mg of rizatriptan, or a molar equivalent amount of a salt of rizatriptan, to a patient with a clear diagnosis of migraine, wherein the patient achieves pain freedom at 2 hours, and wherein the patient does not use another dosage form containing another triptan within 24 hours of administration of the tablet.
(canceled)
4-5. (canceled)
The method of claim 5, wherein the tablet further contains sodium bicarbonate.
7-22. (canceled)
A method of treating migraine, comprising:
- administering a tablet containing 20 mg of meloxicam, about 14.5 mg of rizatriptan benzoate, and sodium bicarbonate, to a human patient with a clear diagnosis of migraine, wherein the patient achieves pain freedom at 2 hours, and wherein the human patient does not use another dosage form containing another triptan within 24 hours of administration of the tablet.
Dependencies are inferred from the claim text.