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US 2026/0216181 A1Published application
Compositions and methods for treating cancer
AssigneesCoiled Therapeutics, Inc., OncoCube Therapeutics LLC
InventorsChaemin Lim, Sridhar Vempati, Erden Banoglu, Burcu Caliskan, Ozgur Sahin
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Abstract
Disclosed herein are inhibitors of TACC and methods of treating certain diseases and disorders (e.g., diseases and disorders related to TACC).
Claims31
1-92. (canceled)
A compound having a structure represented by formula Ia or a pharmaceutically acceptable salt thereof:
- wherein,
- E and B are each independently aryl or heteroaryl;
- D is amino or N-linked heterocyclyl;
- X1 is N or CR2;
- X2 is N or CR3;
- X3 is N or CR4;
- X4 is N or CR5
- R1 is H;
- and
- R2, R3, R4, and R5 are each H.
7 more elements
Dependencies are inferred from the claim text.