Quinoline derivative compounds or pharmaceutically acceptable salt thereof, preparation method therefor and use thereof

A quinoline derivative compound or a pharmaceutically acceptable salt thereof, having the structural formula as shown in Formula I:

• wherein:
• A1, A2, A3, A4 and A5 are each independently selected from N or C—R1, wherein A1, A2, A3, A4 and A5 comprise no more than 2 N;
• R1 is selected from hydrogen, deuterium, halogen, cyano, amino, hydroxyl, nitro, C1-C3 alkyl, C1-C3 alkanoyl, C1-C3 alkylsulfonyl, C1-C3 alkylamino, C1-C3 alkylphosphate, C1-C3 alkylaminosulfonyl, aminosulfonyl, C1-C3 alkoxy and phosphate;
• wherein the C1-C3 alkyl, C1-C3 alkanoyl, C1-C3 alkylsulfonyl, C1-C3 alkylamino, C1-C3 alkylphosphate, C1-C3 alkylaminosulfonyl, C1-C3 alkoxy are each independently substituted with one or more same or different substituents selected from C1-C3 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, C3-C6 heterocycloalkyl, deuterium, halogen, cyano, amino, hydroxyl and nitro;
• R2 is selected from hydrogen, alkyl, cycloalkyl and heterocycloalkyl;
• wherein the alkyl, cycloalkyl and heterocycloalkyl are each independently substituted with one or more same or different substituents selected from halogen, hydroxyl, carboxyl, ester group, alkyl, alkoxy, deuterium, haloalkyl, haloalkoxy, nitro, amino and cyano;
• R3 and R4 are each independently selected from cyano, hydroxyl, C1-C3 alkyl, C1-C3 alkanoyl, C1-C3 alkylamino, and C1-C3 alkoxy;
• wherein the C1-C3 alkyl, C1-C3 alkanoyl, C1-C3 alkylamino, and C1-C3 alkoxy are each independently substituted with one or more same or different substituents selected from halogen, hydroxyl, carboxyl, ester group, alkyl, alkoxy, deuterium, haloalkyl, haloalkoxy, nitro, amino and cyano;
• or R3 and R4 are connected to form C3-C6 cycloalkyl or C3-C6 heterocycloalkyl;
• R5 is selected from deuterium, halogen, amino, hydroxyl, nitro, C1-C6 alkyl, C1-C6haloalkyl, C1-C6 alkanoyl, C1-C6 alkylsulfonyl, C1-C6 alkylamino, C1-C6 alkylphosphate, C1-C6 alkylaminosulfonyl, aminosulfonyl and C1-C6 alkoxy;
• R3, R4 and R5 are not all alkyl or cycloalkyl;
• these R6 are the same or different, and are each independently selected from hydrogen, deuterium, halogen, cyano, hydroxylC1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkanoyl, C1-C3 alkylamino, C1-C3 alkylsulfonyl, C1-C3 alkylphosphate, C1-C3 alkylaminosulfonyl, aminosulfonyl, C3-C7 cycloalkyl, C3-C6 heterocycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, phosphate;
• wherein the C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkanoyl, C1-C3 alkylamino, C1-C3 alkylsulfonyl, C1-C3 alkylphosphate, C1-C3 alkylaminosulfonyl, C3-C7 cycloalkyl, C3-C6 heterocycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl are each independently and optionally substituted with one or more same or different substituents selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C7 cycloalkyl, C3-C6 heterocycloalkyl, deuterium, halogen, cyano, amino, hydroxyl, and nitro;
• and
• n=1, 2 or 3.