Back to results
US 2026/0216172 A1Published application
Compounds and method for treating hiv infection
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Servic
InventorsDaniel H. Appella, Marco Robello
Life of this patent
Estimating the term…
Abstract
Disclosed is a compound of formula (I) or salt thereof: Formula (I) for treating or preventing a human immunodeficiency virus (HIV) infection in a mammal, for inhibiting or preventing maturation of an immature human immunodeficiency virus (HIV) to a mature HIV, and for preventing or inhibiting a human immunodeficiency virus (HIV) infection in a mammal having at least one HIV viral particle on a surface thereof.
Claims24
1-26. (canceled)
A compound of formula (I) or a salt thereof:
- wherein
- R1 is H, an alkylcarbonyloxyalkyl group, or a substituted heterocyclyl group, wherein the substituted heterocyclyl group includes one or more substituents selected from the group consisting of nitro, alkyl, halo, cycloalkyl, haloalkyl, hydroxyl, carboxyl, formyloxy, hydroxyalkyl, aldehydo, amino, alkylamino, aminoalkyl, alkylaminoalkyl, dialkylamino, mercapto, alkylmercapto, cyano, cyanoalkyl, and azido,
- R2 is halo, alkylenedioxy, or monohalo- or dihalo-alkylenedioxy;
- and
- R3 is hydrogen or heterocyclylalkylaminocarbonyl, wherein the heterocyclyl moiety is optionally substituted with one or more groups selected from the group consisting of nitro, alkyl, halo, cycloalkyl, haloalkyl, hydroxyl, carboxyl, formyloxy, hydroxyalkyl, aldehydo, amino, alkylamino, aminoalkyl, alkylaminoalkyl, dialkylamino, mercapto, alkylmercapto, cyano, cyanoalkyl, and azido.
2 more elements
Dependencies are inferred from the claim text.