Tetrahydrothiophene derivative and use thereof in medicine

A compound, or a stereoisomer, deuterated compound, solvate, prodrug, metabolite, pharmaceutically acceptable salt or cocrystal thereof, wherein the compound is selected from a compound as represented by general formula (I),

• Q1 is selected from C6-10 aryl, 5- to 10-membered heteroaryl, C5-10 carbocyclyl, 5- to 10-membered heterocyclyl or
• and the aryl, heteroaryl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 5 Rq;
• RQ1 is selected from H, COOH, NRq1Rq2, —C(═O)NRq1Rq2, —S(═O)2NRq1Rq2, OH, ═O, —ORq1, —C(═O)Rq1, —S(═O)2Rq1, —S(═O)(═NRq1)Rq2 or —P(═O)Rq1Rq2;
• Rq1 and Rq2 are each independently selected from H, C1-6 alkyl, C3-6 carbocyclyl, or 4- to 7-membered heterocyclyl, and the alkyl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 4 Rk;
• alternatively, Rq1 and Rq2 are directly linked to form 4- to 7-membered heterocyclyl, and the heterocyclyl is optionally substituted with 1 to 4 Rk;
• B is selected from C6-10 aryl, 5- to 10-membered heteroaryl, C5-10 carbocyclyl, or 5- to 10-membered heterocyclyl, and the aryl, heteroaryl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 4 RB;
• R1 and R2 are each independently selected from H, halogen, CN, OH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —OC1-6 alkyl, —SC1-6 alkyl, C3-6 carbocyclyl, or 3- to 7-membered heterocyclyl, and the alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 4 Rk, provided that R1 and R2 are not both H;
• R3, R4, Rq, and RB are each independently selected from H, deuterium, halogen, CN, OH, NH2, NHC1-6 alkyl, N(C1-6 alkyl)2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —OC1-6 alkyl, —SC1-6 alkyl, C3-7 carbocyclyl, —OC3-7 carbocyclyl, 3- to 7-membered heterocyclyl or —P(═O)Rq1Rq2, and the alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 4 Rk;
• Rk is selected from deuterium, ═O, halogen, CN, OH, NH2, NHC1-6 alkyl, N(C1-6 alkyl)2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, —OC1-6 alkyl, —SC1-6 alkyl, —O—C3-6 carbocyclyl, —O-3- to 7-membered heterocyclyl, —NH—C3-6 carbocyclyl, —NH-3- to 7-membered heterocyclyl, —C1-4 alkylene-C3-6 carbocyclyl, —C1-4 alkylene-3- to 7-membered heterocyclyl, C3-6 carbocyclyl, or 3- to 7-membered heterocyclyl, and the alkyl, alkylene, alkenyl, alkynyl, carbocyclyl or heterocyclyl is optionally substituted with 1 to 4 substituents selected from deuterium, halogen, ═O, CN, OH, NH2, C1-6 alkyl, or C1-6 alkoxy.